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    Apr 21, 2021
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    Biological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives.

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    Authors
    Chanteau, S
    Rose, A
    Djibo, S
    Nato, F
    Boisier, P
    Affiliation
    CERMES, Réseau International Institut Pasteur, PO Box 10887, Niamey, Niger. schanteau@cermes.org
    Issue Date
    2007-09-03
    Submitted date
    2009-03-04
    
    Metadata
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    Journal
    Vaccine
    Abstract
    Laboratory diagnosis is an essential component in surveillance of meningococcal epidemics, as it can inform decision-makers of the Neisseria meningitidis serogroup(s) involved and the most appropriate vaccine to be selected for mass vaccination. However, countries most affected face real limitations in laboratory diagnostics, due to lack of resources. We describe current diagnostic tools and examine their cost-effectiveness for use in an epidemic context. The conclusion is that current WHO recommendations to use only the latex agglutination assay (Pastorex) at epidemic onset is cost-effective, but recently developed rapid diagnostic tests for the major epidemic-causing meningococcal serogroups may prove a breakthrough for the future.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/56173
    DOI
    10.1016/j.vaccine.2007.04.037
    PubMed ID
    17517452
    Additional Links
    http://www.sciencedirect.com/science/journal/0264410X
    Type
    Article
    Language
    en
    ISSN
    0264-410X
    Sponsors
    Epicentre
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2007.04.037
    Scopus Count
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    Laboratory
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