Biological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives.
Affiliation
CERMES, Réseau International Institut Pasteur, PO Box 10887, Niamey, Niger. schanteau@cermes.orgIssue Date
2007-09-03Submitted date
2009-03-04
Metadata
Show full item recordJournal
VaccineAbstract
Laboratory diagnosis is an essential component in surveillance of meningococcal epidemics, as it can inform decision-makers of the Neisseria meningitidis serogroup(s) involved and the most appropriate vaccine to be selected for mass vaccination. However, countries most affected face real limitations in laboratory diagnostics, due to lack of resources. We describe current diagnostic tools and examine their cost-effectiveness for use in an epidemic context. The conclusion is that current WHO recommendations to use only the latex agglutination assay (Pastorex) at epidemic onset is cost-effective, but recently developed rapid diagnostic tests for the major epidemic-causing meningococcal serogroups may prove a breakthrough for the future.Publisher
ElsevierPubMed ID
17517452Additional Links
http://www.sciencedirect.com/science/journal/0264410XType
ArticleLanguage
enISSN
0264-410XSponsors
Epicentreae974a485f413a2113503eed53cd6c53
10.1016/j.vaccine.2007.04.037
Scopus Count
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