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dc.contributor.authorChanteau, S
dc.contributor.authorRose, A
dc.contributor.authorDjibo, S
dc.contributor.authorNato, F
dc.contributor.authorBoisier, P
dc.date.accessioned2009-03-18T10:20:16Z
dc.date.available2009-03-18T10:20:16Z
dc.date.issued2007-09-03
dc.date.submitted2009-03-04
dc.identifier.citationBiological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives. 2007, 25 Suppl 1:A30-6 Vaccineen
dc.identifier.issn0264-410X
dc.identifier.pmid17517452
dc.identifier.doi10.1016/j.vaccine.2007.04.037
dc.identifier.urihttp://hdl.handle.net/10144/56173
dc.description.abstractLaboratory diagnosis is an essential component in surveillance of meningococcal epidemics, as it can inform decision-makers of the Neisseria meningitidis serogroup(s) involved and the most appropriate vaccine to be selected for mass vaccination. However, countries most affected face real limitations in laboratory diagnostics, due to lack of resources. We describe current diagnostic tools and examine their cost-effectiveness for use in an epidemic context. The conclusion is that current WHO recommendations to use only the latex agglutination assay (Pastorex) at epidemic onset is cost-effective, but recently developed rapid diagnostic tests for the major epidemic-causing meningococcal serogroups may prove a breakthrough for the future.
dc.description.sponsorshipEpicentreen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/journal/0264410Xen
dc.rightsPublished by Elsevier Archived on this site with kind permission and copyright 2007 from Elsevieren
dc.subject.meshAfricaen
dc.subject.meshHumansen
dc.subject.meshLatex Fixation Testsen
dc.subject.meshLeukocyte Counten
dc.subject.meshMeningitis, Meningococcalen
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshSensitivity and Specificityen
dc.titleBiological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives.en
dc.typeArticleen
dc.contributor.departmentCERMES, Réseau International Institut Pasteur, PO Box 10887, Niamey, Niger. schanteau@cermes.orgen
dc.identifier.journalVaccineen
refterms.dateFOA2019-03-04T12:32:01Z
html.description.abstractLaboratory diagnosis is an essential component in surveillance of meningococcal epidemics, as it can inform decision-makers of the Neisseria meningitidis serogroup(s) involved and the most appropriate vaccine to be selected for mass vaccination. However, countries most affected face real limitations in laboratory diagnostics, due to lack of resources. We describe current diagnostic tools and examine their cost-effectiveness for use in an epidemic context. The conclusion is that current WHO recommendations to use only the latex agglutination assay (Pastorex) at epidemic onset is cost-effective, but recently developed rapid diagnostic tests for the major epidemic-causing meningococcal serogroups may prove a breakthrough for the future.


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