The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource Constrained Settings: A Perspective from the Field
Authors
van Griensven, JohanDe Weiggheleire, Anja
Delamou, Alexandre
Smith, Peter G
Edwards, Tansy
Vandekerckhove, Philippe
Ibrahima Bah, Elhadj
Colebunders, Robert
Herve, Isola
Lazaygues, Catherine
Haba, Nyankoye
Lynen, Lutgarde
Issue Date
2015-08-10
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Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of AmericaAbstract
The clinical evaluation of convalescent plasma (CP) for the treatment of Ebola Virus Disease (EVD) in the current outbreak, predominantly affecting Guinea, Sierra Leone and Liberia, was prioritized by the World Health Organization in September 2014. In each of these countries, non-randomized comparative clinical trials were initiated. The Ebola-Tx trial in Conakry, Guinea enrolled 102 patients by July 7, 2015; no severe adverse reactions were noted. The Ebola-CP trial in Sierra Leone and the EVD001 trial in Liberia have included few patients. While no efficacy data are available yet, current field experience supports the safety, acceptability and feasibility of CP as EVD treatment. Longer-term follow-up as well as data from non-trial settings and evidence on the scalability of the intervention are required. CP sourced from within the outbreak is the most readily available source of anti-EVD antibodies. Until the advent of effective antivirals or monoclonal antibodies, CP merits further evaluation.Publisher
Oxford University PressPubMed ID
26261205Language
enISSN
1537-6591ae974a485f413a2113503eed53cd6c53
10.1093/cid/civ680
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