• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Other Diseases
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Other Diseases
    • View Item
    Jan 26, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource Constrained Settings: A Perspective from the Field

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    van Griensven et al - 2015 - The ...
    Size:
    741.1Kb
    Format:
    PDF
    Download
    Authors
    van Griensven, Johan
    De Weiggheleire, Anja
    Delamou, Alexandre
    Smith, Peter G
    Edwards, Tansy
    Vandekerckhove, Philippe
    Ibrahima Bah, Elhadj
    Colebunders, Robert
    Herve, Isola
    Lazaygues, Catherine
    Haba, Nyankoye
    Lynen, Lutgarde
    Show allShow less
    Issue Date
    2015-08-10
    
    Metadata
    Show full item record
    Journal
    Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America
    Abstract
    The clinical evaluation of convalescent plasma (CP) for the treatment of Ebola Virus Disease (EVD) in the current outbreak, predominantly affecting Guinea, Sierra Leone and Liberia, was prioritized by the World Health Organization in September 2014. In each of these countries, non-randomized comparative clinical trials were initiated. The Ebola-Tx trial in Conakry, Guinea enrolled 102 patients by July 7, 2015; no severe adverse reactions were noted. The Ebola-CP trial in Sierra Leone and the EVD001 trial in Liberia have included few patients. While no efficacy data are available yet, current field experience supports the safety, acceptability and feasibility of CP as EVD treatment. Longer-term follow-up as well as data from non-trial settings and evidence on the scalability of the intervention are required. CP sourced from within the outbreak is the most readily available source of anti-EVD antibodies. Until the advent of effective antivirals or monoclonal antibodies, CP merits further evaluation.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/575434
    DOI
    10.1093/cid/civ680
    PubMed ID
    26261205
    Language
    en
    ISSN
    1537-6591
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/civ680
    Scopus Count
    Collections
    Other Diseases

    entitlement

    Related articles

    • Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea.
    • Authors: van Griensven J, Edwards T, de Lamballerie X, Semple MG, Gallian P, Baize S, Horby PW, Raoul H, Magassouba N, Antierens A, Lomas C, Faye O, Sall AA, Fransen K, Buyze J, Ravinetto R, Tiberghien P, Claeys Y, De Crop M, Lynen L, Bah EI, Smith PG, Delamou A, De Weggheleire A, Haba N, Ebola-Tx Consortium.
    • Issue date: 2016 Jan 7
    • Evaluating large-scale blood transfusion therapy for the current Ebola epidemic in Liberia.
    • Authors: Gutfraind A, Meyers LA
    • Issue date: 2015 Apr 15
    • The ongoing evolution of antibody-based treatments for Ebola virus infection.
    • Authors: Mendoza EJ, Racine T, Kobinger GP
    • Issue date: 2017 Mar
    • Treatment of ebola virus disease.
    • Authors: Kilgore PE, Grabenstein JD, Salim AM, Rybak M
    • Issue date: 2015 Jan
    • Anti-Ebola Virus Antibody Levels in Convalescent Plasma and Viral Load After Plasma Infusion in Patients With Ebola Virus Disease.
    • Authors: Brown JF, Dye JM, Tozay S, Jeh-Mulbah G, Wohl DA, Fischer WA 2nd, Cunningham CK, Rowe K, Zacharias P, van Hasselt J, Norwood DA, Thielman NM, Zak SE, Hoover DL
    • Issue date: 2018 Jul 13
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.