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    Apr 11, 2021
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    Dilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settings

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    Shanks et al - 2015 - Dilution ...
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    Authors
    Shanks, L
    Siddiqui, MR
    Abebe, A
    Piriou, E
    Pearce, N
    Ariti, C
    Masiga, J
    Muluneh, L
    Wazome, J
    Ritmeijer, K
    Klarkowski, D
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    Issue Date
    2015-05-14
    
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    Journal
    Virology Journal
    Abstract
    Current WHO testing guidelines for resource limited settings diagnose HIV on the basis of screening tests without a confirmation test due to cost constraints. This leads to a potential risk of false positive HIV diagnosis. In this paper, we evaluate the dilution test, a novel method for confirmation testing, which is simple, rapid, and low cost. The principle of the dilution test is to alter the sensitivity of a rapid diagnostic test (RDT) by dilution of the sample, in order to screen out the cross reacting antibodies responsible for falsely positive RDT results.
    Publisher
    BioMed Central
    URI
    http://hdl.handle.net/10144/600287
    DOI
    10.1186/s12985-015-0306-4
    PubMed ID
    25972188
    Type
    Article
    Language
    en
    ISSN
    1743-422X
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12985-015-0306-4
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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