Dilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settings
Authors
Shanks, LSiddiqui, MR
Abebe, A
Piriou, E
Pearce, N
Ariti, C
Masiga, J
Muluneh, L
Wazome, J
Ritmeijer, K
Klarkowski, D
Issue Date
2015-05-14
Metadata
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Virology JournalAbstract
Current WHO testing guidelines for resource limited settings diagnose HIV on the basis of screening tests without a confirmation test due to cost constraints. This leads to a potential risk of false positive HIV diagnosis. In this paper, we evaluate the dilution test, a novel method for confirmation testing, which is simple, rapid, and low cost. The principle of the dilution test is to alter the sensitivity of a rapid diagnostic test (RDT) by dilution of the sample, in order to screen out the cross reacting antibodies responsible for falsely positive RDT results.Publisher
BioMed CentralPubMed ID
25972188Type
ArticleLanguage
enISSN
1743-422Xae974a485f413a2113503eed53cd6c53
10.1186/s12985-015-0306-4
Scopus Count
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