Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies
Authors
Burri, CYeramian, P D
Allen, J L
Merolle, A
Serge, K K
Mpanya, A
Lutumba, P
Mesu, V K
Bilenge, C M
Lubaki, J P
Mpoto, A M
Thompson, M
Munungu, B F
Manuel, F
Josenando, T
Bernhard, S C
Olson, C A
Blum, J
Tidwell, R R
Pohlig, G
Issue Date
2016-02-16
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PLoS Neglected Tropical DiseasesAbstract
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death. We conducted two Phase 2 studies to determine the efficacy and safety of oral pafuramidine in African patients with first stage HAT.Publisher
Public Library of SciencePubMed ID
26881924Type
ArticleLanguage
enISSN
1935-2735ae974a485f413a2113503eed53cd6c53
10.1371/journal.pntd.0004362
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