• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Trypanosomiasis/Sleeping Sickness
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Trypanosomiasis/Sleeping Sickness
    • View Item
    Apr 11, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Burri et al - 2016 - Efficacy, ...
    Size:
    1.039Mb
    Format:
    PDF
    Download
    Authors
    Burri, C
    Yeramian, P D
    Allen, J L
    Merolle, A
    Serge, K K
    Mpanya, A
    Lutumba, P
    Mesu, V K
    Bilenge, C M
    Lubaki, J P
    Mpoto, A M
    Thompson, M
    Munungu, B F
    Manuel, F
    Josenando, T
    Bernhard, S C
    Olson, C A
    Blum, J
    Tidwell, R R
    Pohlig, G
    Show allShow less
    Issue Date
    2016-02-16
    
    Metadata
    Show full item record
    Journal
    PLoS Neglected Tropical Diseases
    Abstract
    Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death. We conducted two Phase 2 studies to determine the efficacy and safety of oral pafuramidine in African patients with first stage HAT.
    Publisher
    Public Library of Science
    URI
    http://hdl.handle.net/10144/601276
    DOI
    10.1371/journal.pntd.0004362
    PubMed ID
    26881924
    Type
    Article
    Language
    en
    ISSN
    1935-2735
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pntd.0004362
    Scopus Count
    Collections
    Trypanosomiasis/Sleeping Sickness

    entitlement

    Related articles

    • Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.
    • Authors: Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, Lubaki JP, Mpoto AM, Munungu BF, N'tombe PM, Deo GK, Mutantu PN, Kuikumbi FM, Mintwo AF, Munungi AK, Dala A, Macharia S, Bilenge CM, Mesu VK, Franco JR, Dituvanga ND, Tidwell RR, Olson CA
    • Issue date: 2016 Feb
    • Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis.
    • Authors: Thuita JK, Karanja SM, Wenzler T, Mdachi RE, Ngotho JM, Kagira JM, Tidwell R, Brun R
    • Issue date: 2008 Oct
    • Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.
    • Authors: Mdachi RE, Thuita JK, Kagira JM, Ngotho JM, Murilla GA, Ndung'u JM, Tidwell RR, Hall JE, Brun R
    • Issue date: 2009 Mar
    • Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.
    • Authors: Thuita JK, Wang MZ, Kagira JM, Denton CL, Paine MF, Mdachi RE, Murilla GA, Ching S, Boykin DW, Tidwell RR, Hall JE, Brun R
    • Issue date: 2012
    • Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.
    • Authors: Priotto G, Kasparian S, Mutombo W, Ngouama D, Ghorashian S, Arnold U, Ghabri S, Baudin E, Buard V, Kazadi-Kyanza S, Ilunga M, Mutangala W, Pohlig G, Schmid C, Karunakara U, Torreele E, Kande V
    • Issue date: 2009 Jul 4
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.