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    Apr 21, 2021
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    Outcomes of Antiretroviral Therapy Among Younger Versus Older Adolescents and Adults in an Urban Clinic, Zimbabwe

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    Matyanga et al - 2016 - Outcomes ...
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    Authors
    Matyanga, C M J
    Takarinda, K C
    Owiti, P
    Mutasa-Apollo, T
    Mugurungi, O
    Buruwe, L
    Reid, A J
    Issue Date
    2016-06-21
    Submitted date
    2016-06-29
    
    Metadata
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    Journal
    Public Health Action
    Abstract
    Setting: A non-governmental organisation-supported clinic offering health services including antiretroviral therapy (ART). Objective: To compare ART retention between younger (age 10–14 years) vs. older (age 15–19 years) adolescents and younger (age 20–29 years) vs. older (age 30 years) adults and determine adolescent- and adult-specific attrition-associated factors among those initiated on ART between 2010 and 2011. Design: Retrospective cohort study. Results: Of 110 (7%) adolescents and 1484 (93%) adults included in the study, no differences in retention were observed between younger vs. older adolescents at 6, 12 and 24 months. More younger adolescents were initiated with body mass index 16 kg/m2 compared with older adolescents (64% vs. 47%; P = 0.04). There were more females (74% vs. 52%, P  0.001) and fewer patients initiating ART with CD4 count 350 cells/mm3 (77% vs. 81%, P = 0.007) among younger vs. older adults. Younger adults demonstrated more attrition than older adults at all time-points. No attrition risk factors were observed among adolescents. Attrition-associated factors among adults included being younger, having a lower CD4 count and advanced human immunodeficiency virus disease at initiation, and initiation on a stavudine-based regimen. Conclusion: Younger adults demonstrated greater attrition and may require more attention. We were unable to demonstrate differences in attrition among younger vs. older adolescents. Loss to follow-up was the main reason for attrition across all age groups. Overall, earlier presentation for ART care appears important for improved ART retention among adults.
    Publisher
    International Union Against TB and Lung Disease
    URI
    http://hdl.handle.net/10144/615907
    DOI
    10.5588/pha.15.0077
    Additional Links
    http://openurl.ingenta.com/content/xref?genre=article&issn=2220-8372&volume=6&issue=2&spage=97
    Language
    en
    ISSN
    22208372
    22208372
    ae974a485f413a2113503eed53cd6c53
    10.5588/pha.15.0077
    Scopus Count
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    Operational Research Courses

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