Selection of Plasmodium Falciparum pfcrt and pfmdr1 Polymorphisms After Treatment with Artesunate-Amodiaquine Fixed Dose Combination or Artemether-Lumefantrine in Liberia
Authors
Otienoburu, SDMaïga-Ascofaré, O
Schramm, B
Jullien, V
Jones, JJ
Zolia, YM
Houzé, P
Ashley, EA
Kiechel, JR
Guérin, PJ
Le Bras, J
Houzé, S
Issue Date
2016-09-05Submitted date
2016-09-12
Metadata
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Malaria JournalAbstract
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the different ACT compounds; the artemisinin derivative and the partner drug. Studies of P. falciparum polymorphisms associated with drug resistance can provide a useful tool to track resistance and guide treatment policy as well as an in-depth understanding of the development and spread of resistance.Publisher
BioMed Central (Springer Science)PubMed ID
27596849Language
enISSN
1475-2875ae974a485f413a2113503eed53cd6c53
10.1186/s12936-016-1503-3
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