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    Jan 19, 2021
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    An Optimised Age-Based Dosing Regimen for Single Low-Dose Primaquine For Blocking Malaria Transmission in Cambodia

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    Leang R et al - 2016 - An optimized ...
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    Authors
    Leang, R
    Khu, NH
    Mukaka, M
    Debackere, M
    Tripura, R
    Kheang, ST
    Chy, S
    Kak, N
    Buchy, P
    Tarantola, A
    Menard, D
    Roca-Felterer, A
    Fairhurst, RM
    Kheng, S
    Muth, S
    Ngak, S
    Dondorp, AM
    White, NJ
    Taylor, WRJ
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    Issue Date
    2016-10-27
    Submitted date
    2016-10-31
    
    Metadata
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    Journal
    BMC Medicine
    Abstract
    In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was non-pregnant patients aged ≥ 1 year (later changed to ≥ 6 months) with acute uncomplicated falciparum malaria, primarily in countries with artemisinin-resistant P. falciparum (ARPf). No dosing regimen was suggested, leaving malaria control programmes and clinicians in limbo. Therefore, we designed a user-friendly, age-based SLDPQ regimen for Cambodia, the country most affected by ARPf.
    Publisher
    BioMed Central
    URI
    http://hdl.handle.net/10144/618686
    DOI
    10.1186/s12916-016-0701-8
    PubMed ID
    27784313
    Language
    en
    ISSN
    1741-7015
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12916-016-0701-8
    Scopus Count
    Collections
    Malaria

    entitlement

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