An Optimised Age-Based Dosing Regimen for Single Low-Dose Primaquine For Blocking Malaria Transmission in Cambodia
Authors
Leang, RKhu, NH
Mukaka, M
Debackere, M
Tripura, R
Kheang, ST
Chy, S
Kak, N
Buchy, P
Tarantola, A
Menard, D
Roca-Felterer, A
Fairhurst, RM
Kheng, S
Muth, S
Ngak, S
Dondorp, AM
White, NJ
Taylor, WRJ
Issue Date
2016-10-27Submitted date
2016-10-31
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BMC MedicineAbstract
In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was non-pregnant patients aged ≥ 1 year (later changed to ≥ 6 months) with acute uncomplicated falciparum malaria, primarily in countries with artemisinin-resistant P. falciparum (ARPf). No dosing regimen was suggested, leaving malaria control programmes and clinicians in limbo. Therefore, we designed a user-friendly, age-based SLDPQ regimen for Cambodia, the country most affected by ARPf.Publisher
BioMed CentralPubMed ID
27784313Language
enISSN
1741-7015ae974a485f413a2113503eed53cd6c53
10.1186/s12916-016-0701-8
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