Immune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan
Authors
Iyer, ASBouhenia, M
Rumunu, J
Abubakar, A
Gruninger, RJ
Pita, J
Lino, RL
Deng, LL
Wamala, JF
Ryan, ET
Martin, S
Legros, D
Lessler, J
Sack, DA
Luquero, FJ
Leung, DT
Azman, AS
Issue Date
2016-10-24Submitted date
2016-10-31
Metadata
Show full item recordJournal
Scientific ReportsAbstract
Despite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera risk. During a 2015 preemptive OCV campaign among internally displaced persons in South Sudan, a year after a large cholera outbreak, we enrolled 37 young children (1-5 years old), 67 older children (6-17 years old) and 101 adults (≥18 years old), who received two doses of OCV (Shanchol) spaced approximately 3 weeks apart. Cholera-specific antibody responses were determined at days 0, 21 and 35 post-immunization. High baseline vibriocidal titers (>80) were observed in 21% of the participants, suggesting recent cholera exposure or vaccination. Among those with titers ≤80, 90% young children, 73% older children and 72% adults seroconverted (≥4 fold titer rise) after the 1(st) OCV dose; with no additional seroconversion after the 2(nd) dose. Post-vaccination immunological endpoints did not differ across age groups. Our results indicate Shanchol was immunogenic in this vulnerable population and that a single dose alone may be sufficient to achieve similar short-term immunological responses to the currently licensed two-dose regimen. While we found no evidence of differential response by age, further immunologic and epidemiologic studies are needed.Publisher
Nature Publishing GroupPubMed ID
27775046Language
enISSN
2045-2322ae974a485f413a2113503eed53cd6c53
10.1038/srep35742
Scopus Count
Collections
Related articles
- Safety and immunogenicity of the killed bivalent (O1 and O139) whole-cell cholera vaccine in the Philippines.
- Authors: Capeding MRZ, Gonzales MLAM, Dhingra MS, D'Cor NA, Midde VJ, Patnaik BN, Thollot Y, Desauziers E
- Issue date: 2017 Oct 3
- Population-Level Effect of Cholera Vaccine on Displaced Populations, South Sudan, 2014.
- Authors: Azman AS, Rumunu J, Abubakar A, West H, Ciglenecki I, Helderman T, Wamala JF, Vázquez Ode L, Perea W, Sack DA, Legros D, Martin S, Lessler J, Luquero FJ
- Issue date: 2016 Jun
- Vibriocidal antibody responses to a bivalent killed whole-cell oral cholera vaccine in a phase III trial in Kolkata, India.
- Authors: Kanungo S, Lopez AL, Ali M, Manna B, Kim DR, Mahapatra T, Holmgren J, Dhingra MS, Weirzba TF, Nair GB, Bhattacharya SK, Clemens JD, Sur D
- Issue date: 2014
- An Open Label Non-inferiority Trial Assessing Vibriocidal Response of a Killed Bivalent Oral Cholera Vaccine Regimen following a Five Year Interval in Kolkata, India.
- Authors: Kanungo S, Desai SN, Saha J, Nandy RK, Sinha A, Kim DR, Bannerjee B, Manna B, Yang JS, Ali M, Sur D, Wierzba TF
- Issue date: 2015 May
- Immunogenicity of a killed bivalent (O1 and O139) whole cell oral cholera vaccine, Shanchol, in Haiti.
- Authors: Charles RC, Hilaire IJ, Mayo-Smith LM, Teng JE, Jerome JG, Franke MF, Saha A, Yu Y, Kováč P, Calderwood SB, Ryan ET, LaRocque RC, Almazor CP, Qadri F, Ivers LC, Harris JB
- Issue date: 2014 May