Show simple item record

dc.contributor.authorIyer, AS
dc.contributor.authorBouhenia, M
dc.contributor.authorRumunu, J
dc.contributor.authorAbubakar, A
dc.contributor.authorGruninger, RJ
dc.contributor.authorPita, J
dc.contributor.authorLino, RL
dc.contributor.authorDeng, LL
dc.contributor.authorWamala, JF
dc.contributor.authorRyan, ET
dc.contributor.authorMartin, S
dc.contributor.authorLegros, D
dc.contributor.authorLessler, J
dc.contributor.authorSack, DA
dc.contributor.authorLuquero, FJ
dc.contributor.authorLeung, DT
dc.contributor.authorAzman, AS
dc.date.accessioned2016-11-06T13:10:34Z
dc.date.available2016-11-06T13:10:34Z
dc.date.issued2016-10-24
dc.date.submitted2016-10-31
dc.identifier.citationImmune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan. 2016, 6:35742 Sci Repen
dc.identifier.issn2045-2322
dc.identifier.pmid27775046
dc.identifier.doi10.1038/srep35742
dc.identifier.urihttp://hdl.handle.net/10144/618687
dc.description.abstractDespite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera risk. During a 2015 preemptive OCV campaign among internally displaced persons in South Sudan, a year after a large cholera outbreak, we enrolled 37 young children (1-5 years old), 67 older children (6-17 years old) and 101 adults (≥18 years old), who received two doses of OCV (Shanchol) spaced approximately 3 weeks apart. Cholera-specific antibody responses were determined at days 0, 21 and 35 post-immunization. High baseline vibriocidal titers (>80) were observed in 21% of the participants, suggesting recent cholera exposure or vaccination. Among those with titers ≤80, 90% young children, 73% older children and 72% adults seroconverted (≥4 fold titer rise) after the 1(st) OCV dose; with no additional seroconversion after the 2(nd) dose. Post-vaccination immunological endpoints did not differ across age groups. Our results indicate Shanchol was immunogenic in this vulnerable population and that a single dose alone may be sufficient to achieve similar short-term immunological responses to the currently licensed two-dose regimen. While we found no evidence of differential response by age, further immunologic and epidemiologic studies are needed.
dc.languageENG
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsArchived with thanks to Scientific reportsen
dc.titleImmune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudanen
dc.identifier.journalScientific Reportsen
refterms.dateFOA2019-03-04T12:56:26Z
html.description.abstractDespite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera risk. During a 2015 preemptive OCV campaign among internally displaced persons in South Sudan, a year after a large cholera outbreak, we enrolled 37 young children (1-5 years old), 67 older children (6-17 years old) and 101 adults (≥18 years old), who received two doses of OCV (Shanchol) spaced approximately 3 weeks apart. Cholera-specific antibody responses were determined at days 0, 21 and 35 post-immunization. High baseline vibriocidal titers (>80) were observed in 21% of the participants, suggesting recent cholera exposure or vaccination. Among those with titers ≤80, 90% young children, 73% older children and 72% adults seroconverted (≥4 fold titer rise) after the 1(st) OCV dose; with no additional seroconversion after the 2(nd) dose. Post-vaccination immunological endpoints did not differ across age groups. Our results indicate Shanchol was immunogenic in this vulnerable population and that a single dose alone may be sufficient to achieve similar short-term immunological responses to the currently licensed two-dose regimen. While we found no evidence of differential response by age, further immunologic and epidemiologic studies are needed.


Files in this item

Thumbnail
Name:
Iyer et al - 2016 - Immune ...
Size:
1.040Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record