Efficacy of Artemether-Lumefantrine in Relation to Drug Exposure in Children With and Without Severe Acute Malnutrition: an Open Comparative Intervention Study in Mali and Niger
Authors
Denoeud-Ndam, LDicko, A
Baudin, E
Guindo, O
Grandesso, F
Diawara, H
Sissoko, S
Sanogo, K
Traoré, S
Keita, S
Barry, A
de Smet, M
Lasry, E
Smit, M
Wiesner, L
Barnes, KI
Djimde, AA
Guerin, PJ
Grais, RF
Doumbo, OK
Etard, JF
Issue Date
2016-10-24Submitted date
2016-10-31
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BMC MedicineAbstract
Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy in children with SAM compared to those without.Publisher
BioMed CentralPubMed ID
27776521Language
enISSN
1741-7015ae974a485f413a2113503eed53cd6c53
10.1186/s12916-016-0716-1
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