• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • TB
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • TB
    • View Item
    Apr 11, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Multidrug-Resistant Tuberculosis Treatment Failure Detection Depends on Monitoring Interval and Microbiological Method

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Mitnick et al - 2016 - Multidr ...
    Size:
    477.7Kb
    Format:
    PDF
    Download
    Authors
    Mitnick, CD
    White, RA
    Lu, C
    Rodriguez, CA
    Bayona, J
    Becerra, MC
    Burgos, M
    Centis, R
    Cohen, T
    Cox, H
    D'Ambrosio, L
    Danilovitz, M
    Falzon, D
    Gelmanova, IY
    Gler, MT
    Grinsdale, JA
    Holtz, TH
    Keshavjee, S
    Leimane, V
    Menzies, D
    Migliori, GB
    Milstein, MB
    Mishustin, SP
    Pagano, M
    Quelapio, MI
    Shean, K
    Shin, SS
    Tolman, AW
    van der Walt, ML
    Van Deun, A
    Viiklepp, P
    Show allShow less
    Issue Date
    2016-09-01
    Submitted date
    2016-09-06
    
    Metadata
    Show full item record
    Journal
    European Respiratory Journal
    Abstract
    Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection.We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to estimate pooled relative risk of failure detection in the last 12 months of treatment; hazard of failure using monthly culture was the reference.Data were obtained for 5410 patients across 12 observational studies. During the last 12 months of treatment, failure detection occurred in a median of 3 months by monthly culture; failure detection was delayed by 2, 7, and 9 months relying on bimonthly culture, monthly smear and bimonthly smear, respectively. Risk (95% CI) of failure detection delay resulting from monthly smear relative to culture is 0.38 (0.34-0.42) for all patients and 0.33 (0.25-0.42) for HIV-co-infected patients.Failure detection is delayed by reducing the sensitivity and frequency of the monitoring method. Monthly monitoring of sputum cultures from patients receiving MDR-TB treatment is recommended. Expanded laboratory capacity is needed for high-quality culture, and for smear microscopy and rapid molecular tests.
    Publisher
    European Respiratory Society
    URI
    http://hdl.handle.net/10144/618725
    DOI
    10.1183/13993003.00462-2016
    PubMed ID
    27587552
    Language
    en
    ISSN
    1399-3003
    ae974a485f413a2113503eed53cd6c53
    10.1183/13993003.00462-2016
    Scopus Count
    Collections
    TB

    entitlement

    Related articles

    • Body mass index predictive of sputum culture conversion among MDR-TB patients in Indonesia.
    • Authors: Putri FA, Burhan E, Nawas A, Soepandi PZ, Sutoyo DK, Agustin H, Isbaniah F, Dowdy DW
    • Issue date: 2014 May
    • Impact of the human immunodeficiency virus on early multidrug-resistant tuberculosis treatment outcomes in Botswana.
    • Authors: Hafkin J, Modongo C, Newcomb C, Lowenthal E, MacGregor RR, Steenhoff AP, Friedman H, Bisson GP
    • Issue date: 2013 Mar
    • Predictors of sputum culture conversion among patients treated for multidrug-resistant tuberculosis.
    • Authors: Kurbatova EV, Gammino VM, Bayona J, Becerra MC, Danilovitz M, Falzon D, Gelmanova I, Keshavjee S, Leimane V, Mitnick CD, Quelapio MI, Riekstina V, Taylor A, Viiklepp P, Zignol M, Cegielski JP
    • Issue date: 2012 Oct
    • Rapid impact of effective treatment on transmission of multidrug-resistant tuberculosis.
    • Authors: Dharmadhikari AS, Mphahlele M, Venter K, Stoltz A, Mathebula R, Masotla T, van der Walt M, Pagano M, Jensen P, Nardell E
    • Issue date: 2014 Sep
    • Sublineages of Mycobacterium tuberculosis Beijing genotype strains and unfavorable outcomes of anti-tuberculosis treatment.
    • Authors: Hang NT, Maeda S, Keicho N, Thuong PH, Endo H
    • Issue date: 2015 May
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.