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    Mar 03, 2021
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    Ebola Virus Disease, Democratic Republic of the Congo, 2014

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    Nanclares et al - 2016 - Ebola ...
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    Authors
    Nanclares, C
    Kapetshi, J
    Lionetto, F
    de la Rosa, O
    Tamfun, JJ
    Alia, M
    Kobinger, G
    Bernasconi, A
    Issue Date
    2016-09
    
    Metadata
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    Journal
    Emerging Infectious Diseases
    Abstract
    During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.
    Publisher
    Center for Disease Control
    URI
    http://hdl.handle.net/10144/618726
    DOI
    10.3201/eid2209.160354
    PubMed ID
    27533284
    Language
    en
    ISSN
    1080-6059
    ae974a485f413a2113503eed53cd6c53
    10.3201/eid2209.160354
    Scopus Count
    Collections
    Other Diseases

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