Adapting to the Global Shortage of Cholera Vaccines: Targeted Single Dose Cholera Vaccine in Response to an Outbreak in South Sudan
Authors
Parker, LARumunu, J
Jamet, C
Kenyi, Y
Lino, RL
Wamala, JF
Mpairwe, AM
Ciglenecki, I
Luquero, FJ
Azman, AS
Cabrol, JC
Issue Date
2017-01-18Submitted date
2017-01-25
Metadata
Show full item recordJournal
The Lancet. Infectious DiseasesAbstract
Shortages of vaccines for epidemic diseases, such as cholera, meningitis, and yellow fever, have become common over the past decade, hampering efforts to control outbreaks through mass reactive vaccination campaigns. Additionally, various epidemiological, political, and logistical challenges, which are poorly documented in the literature, often lead to delays in reactive campaigns, ultimately reducing the effect of vaccination. In June 2015, a cholera outbreak occurred in Juba, South Sudan, and because of the global shortage of oral cholera vaccine, authorities were unable to secure sufficient doses to vaccinate the entire at-risk population-approximately 1 million people. In this Personal View, we document the first public health use of a reduced, single-dose regimen of oral cholera vaccine, and show the details of the decision-making process and timeline. We also make recommendations to help improve reactive vaccination campaigns against cholera, and discuss the importance of new and flexible context-specific dose regimens and vaccination strategies.Publisher
ElsevierPubMed ID
28109819Language
enISSN
1474-4457ae974a485f413a2113503eed53cd6c53
10.1016/S1473-3099(16)30472-8