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    Jan 26, 2021
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    Thiamine Deficiency in Tropical Pediatrics: New Insights into a Neglected but Vital Metabolic Challenge

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    Hiffler L et al - 2016 - Thiamine ...
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    Authors
    Hiffler, L
    Rakotoambinina, B
    Lafferty, N
    Martinez Garcia, D
    Issue Date
    2016-06-14
    
    Metadata
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    Journal
    Frontiers in Nutrition
    Abstract
    In humans, thiamine is a micronutrient prone to depletion that may result in severe clinical abnormalities. This narrative review summarizes current knowledge on thiamine deficiency (TD) and bridges the gap between pathophysiology and clinical presentation by integrating thiamine metabolism at subcellular level with its function to vital organs. The broad clinical spectrum of TD is outlined, with emphasis on conditions encountered in tropical pediatric practice. In particular, TD is associated with type B lactic acidosis and classic forms of beriberi in children, but it is often unrecognized. Other severe acute conditions are associated with hypermetabolism, inducing a functional TD. The crucial role of thiamine in infant cognitive development is also highlighted in this review, along with analysis of the potential impact of TD in refeeding syndrome during severe acute malnutrition (SAM). This review aims to increase clinical awareness of TD in tropical settings where access to diagnostic tests is poor, and advocates for an early therapeutic thiamine challenge in resource-limited settings. Moreover, it provides evidence for thiamine as treatment in critical conditions requiring metabolic resuscitation, and gives rationale to the consideration of increased thiamine supplementation in therapeutic foods for malnourished children.
    Publisher
    Frontiers Media
    URI
    http://hdl.handle.net/10144/618771
    DOI
    10.3389/fnut.2016.00016
    PubMed ID
    27379239
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fnut.2016.00016
    Scopus Count
    Collections
    Nutrition

    entitlement

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