First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
Authors
Dörnemann, JBurzio, C
Ronsse, A
Sprecher, A
De Clerck, H
Van Herp, M
Kolié, MC
Yosifiva, V
Caluwaerts, S
McElroy, AK
Antierens, A
Issue Date
2017-01-09Submitted date
2017-01-18
Metadata
Show full item recordAbstract
A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.Publisher
Oxford University PressPubMed ID
28073857Language
enISSN
1537-6613ae974a485f413a2113503eed53cd6c53
10.1093/infdis/jiw493
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