• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Ethics
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Ethics
    • View Item
    Mar 04, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    The Ebola Clinical Trials: a Precedent for Research Ethics in Disasters

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Calain - 2016 - The Ebola clinical ...
    Size:
    309.9Kb
    Format:
    PDF
    Download
    Authors
    Calain, P
    Issue Date
    2016-08-29
    Submitted date
    2016-09-06
    
    Metadata
    Show full item record
    Journal
    Journal of medical ethics
    Abstract
    The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis. This unprecedented effort was supported by the recommendations of an ad hoc ethics panel convened in August 2014 by the WHO. By considering why and on what conditions the exceptional circumstances of the Ebola epidemic justified the use of unproven interventions, the panel's recommendations have challenged conventional thinking about therapeutic development and clinical research ethics. At the same time, unanswered ethical questions have emerged, in particular: (i) the specification of exceptional circumstances, (ii) the specification of unproven interventions, (iii) the goals of interventional research in terms of individual versus collective interests, (iv) the place of adaptive trial designs and (v) the exact meaning of compassionate use with unapproved interventions. Examination of these questions, in parallel with empirical data from research sites, will help build pragmatic foundations for disaster research ethics. Furthermore, the Ebola clinical trials signal an evolution in the current paradigms of therapeutic research, beyond the case of epidemic emergencies.
    Publisher
    BMJ Publishing Group
    URI
    http://hdl.handle.net/10144/618800
    DOI
    10.1136/medethics-2016-103474
    PubMed ID
    27573153
    Language
    en
    ISSN
    1473-4257
    ae974a485f413a2113503eed53cd6c53
    10.1136/medethics-2016-103474
    Scopus Count
    Collections
    Ethics

    entitlement

    Related articles

    • Examining the ethics of clinical use of unproven interventions outside of clinical trials during the Ebola epidemic.
    • Authors: Shah SK, Wendler D, Danis M
    • Issue date: 2015
    • Placing and evaluating unproven interventions within a clinical ethical taxonomy of treatments for Ebola virus disease.
    • Authors: Allen NG, Blumenthal-Barby JS, McCullough LB
    • Issue date: 2015
    • In particular circumstances attempting unproven interventions is permissible and even obligatory.
    • Authors: White BD, Gelinas LC, Shelton WN
    • Issue date: 2015
    • Aspects of disaster research ethics applicable to other contexts.
    • Authors: Haire B
    • Issue date: 2018 Jan
    • Everyday ethics and Ebola: planning for the unlikely.
    • Authors: Keirns CC
    • Issue date: 2015
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.