Authors
Fortuin-de Smidt, Mde Waal, R
Cohen, K
Technau, KG
Stinson, K
Maartens, G
Boulle, A
Igumbor, EU
Davies, MA
Issue Date
2017-02-13Submitted date
2017-02-27
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PloS OneAbstract
There are a limited number of paediatric antiretroviral drug options. Characterising the long term safety and durability of different antiretrovirals in children is important to optimise management of HIV infected children and to determine the estimated need for alternative drugs in paediatric regimens. We describe first-line antiretroviral therapy (ART) durability and reasons for discontinuations in children at two South African ART programmes, where lopinavir/ritonavir has been recommended for children <3 years old since 2004, and abacavir replaced stavudine as the preferred nucleoside reverse transcriptase inhibitor in 2010.Publisher
Public Library of SciencePubMed ID
28192529Language
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0169762
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