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    Jan 26, 2021
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    First-Line Antiretroviral Drug Discontinuations in Children

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    Name:
    Fortuin-de-Smidt M et al - 2017 ...
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    Authors
    Fortuin-de Smidt, M
    de Waal, R
    Cohen, K
    Technau, KG
    Stinson, K
    Maartens, G
    Boulle, A
    Igumbor, EU
    Davies, MA
    Issue Date
    2017-02-13
    Submitted date
    2017-02-27
    
    Metadata
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    Journal
    PloS One
    Abstract
    There are a limited number of paediatric antiretroviral drug options. Characterising the long term safety and durability of different antiretrovirals in children is important to optimise management of HIV infected children and to determine the estimated need for alternative drugs in paediatric regimens. We describe first-line antiretroviral therapy (ART) durability and reasons for discontinuations in children at two South African ART programmes, where lopinavir/ritonavir has been recommended for children <3 years old since 2004, and abacavir replaced stavudine as the preferred nucleoside reverse transcriptase inhibitor in 2010.
    Publisher
    Public Library of Science
    URI
    http://hdl.handle.net/10144/618811
    DOI
    10.1371/journal.pone.0169762
    PubMed ID
    28192529
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0169762
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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