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    Mar 02, 2021
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    Favipiravir Pharmacokinetics in Ebola-Infected Patients of the JIKI Trial Reveals Concentrations Lower Than Targeted

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    Nguyen T et al - 2017 - Favipiravir ...
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    Authors
    Nguyen, TH
    Guedj, J
    Anglaret, X
    Laouénan, C
    Madelain, V
    Taburet, AM
    Baize, S
    Sissoko, D
    Pastorino, B
    Rodallec, A
    Piorkowski, G
    Carazo, S
    Conde, MN
    Gala, JL
    Bore, JA
    Carbonnelle, C
    Jacquot, F
    Raoul, H
    Malvy, D
    de Lamballerie, X
    Mentré, F
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    Issue Date
    2017-02-23
    Submitted date
    2017-02-27
    
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    Journal
    PLoS Neglected Tropical Diseases
    Abstract
    In 2014-2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for this indication and that high concentrations of the drugs were needed to achieve antiviral efficacy against EBOV, a pharmacokinetic model had been used to propose relevant dosing regimen. Here we report the favipiravir plasma concentrations that were achieved in participants in the JIKI trial and put them in perspective with the model-based targeted concentrations.
    Publisher
    PLoS
    URI
    http://hdl.handle.net/10144/618815
    DOI
    10.1371/journal.pntd.0005389
    PubMed ID
    28231247
    Language
    en
    ISSN
    1935-2735
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pntd.0005389
    Scopus Count
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