Favipiravir Pharmacokinetics in Ebola-Infected Patients of the JIKI Trial Reveals Concentrations Lower Than Targeted
Authors
Nguyen, THGuedj, J
Anglaret, X
Laouénan, C
Madelain, V
Taburet, AM
Baize, S
Sissoko, D
Pastorino, B
Rodallec, A
Piorkowski, G
Carazo, S
Conde, MN
Gala, JL
Bore, JA
Carbonnelle, C
Jacquot, F
Raoul, H
Malvy, D
de Lamballerie, X
Mentré, F
Issue Date
2017-02-23Submitted date
2017-02-27
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PLoS Neglected Tropical DiseasesAbstract
In 2014-2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for this indication and that high concentrations of the drugs were needed to achieve antiviral efficacy against EBOV, a pharmacokinetic model had been used to propose relevant dosing regimen. Here we report the favipiravir plasma concentrations that were achieved in participants in the JIKI trial and put them in perspective with the model-based targeted concentrations.Publisher
PLoSPubMed ID
28231247Language
enISSN
1935-2735ae974a485f413a2113503eed53cd6c53
10.1371/journal.pntd.0005389
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