Global Phylogeography and Evolutionary History of Shigella Dysenteriae Type 1
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AbstractTogether with plague, smallpox and typhus, epidemics of dysentery have been a major scourge of human populations for centuries(1). A previous genomic study concluded that Shigella dysenteriae type 1 (Sd1), the epidemic dysentery bacillus, emerged and spread worldwide after the First World War, with no clear pattern of transmission(2). This is not consistent with the massive cyclic dysentery epidemics reported in Europe during the eighteenth and nineteenth centuries(1,3,4) and the first isolation of Sd1 in Japan in 1897(5). Here, we report a whole-genome analysis of 331 Sd1 isolates from around the world, collected between 1915 and 2011, providing us with unprecedented insight into the historical spread of this pathogen. We show here that Sd1 has existed since at least the eighteenth century and that it swept the globe at the end of the nineteenth century, diversifying into distinct lineages associated with the First World War, Second World War and various conflicts or natural disasters across Africa, Asia and Central America. We also provide a unique historical perspective on the evolution of antibiotic resistance over a 100-year period, beginning decades before the antibiotic era, and identify a prevalent multiple antibiotic-resistant lineage in South Asia that was transmitted in several waves to Africa, where it caused severe outbreaks of disease.
PublisherNature Publishing Group
- Genomic analysis of the emergence of 20th century epidemic dysentery.
- Authors: Rohmer L, Jacobs MA, Brittnacher MJ, Fong C, Hayden HS, Hocquet D, Weiss EJ, Radey M, Germani Y, Talukder KA, Hager AJ, Kemner JM, Sims-Day EH, Matamouros S, Hager KR, Miller SI
- Issue date: 2014 May 10
- Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri.
- Authors: Connor TR, Barker CR, Baker KS, Weill FX, Talukder KA, Smith AM, Baker S, Gouali M, Pham Thanh D, Jahan Azmi I, Dias da Silveira W, Semmler T, Wieler LH, Jenkins C, Cravioto A, Faruque SM, Parkhill J, Wook Kim D, Keddy KH, Thomson NR
- Issue date: 2015 Aug 4
- [The world-wide pandemic and drug resistance of the causative agent of Grigor'ev-Shiga dysentery].
- Authors: Solodovnikov IuP, Myl'nikova GS
- Issue date: 1988 Nov
- Multidrug-resistant Shigella dysenteriae type 1 in south Asia.
- Authors: Bhattacharya SK, Sarkar K, Balakrish Nair G, Faruque AS, Sack DA
- Issue date: 2003 Dec
- The spread of Shigella dysenteriae type I in Africa.
- Authors: Wittenberg DF
- Issue date: 1998