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    Jan 19, 2021
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    Clinical Chemistry of Patients With Ebola in Monrovia, Liberia

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    de Wit et al - 2016 - Clinical ...
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    Authors
    de Wit, E
    Kramer, S
    Prescott, J
    Rosenke, K
    Falzarano, D
    Marzi, A
    Fischer, RJ
    Safronetz, D
    Hoenen, T
    Groseth, A
    van Doremalen, N
    Bushmaker, T
    McNally, KL
    Feldmann, F
    Williamson, BN
    Best, SM
    Ebihara, H
    Damiani, IA
    Adamson, B
    Zoon, KC
    Nyenswah, TG
    Bolay, FK
    Massaquoi, M
    Sprecher, A
    Feldmann, H
    Munster, VJ
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    Issue Date
    2016-07-28
    Submitted date
    2016-08-03
    
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    Journal
    Journal of Infectious Diseases
    Abstract
    The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/618821
    DOI
    10.1093/infdis/jiw187
    PubMed ID
    27471319
    Language
    en
    ISSN
    1537-6613
    ae974a485f413a2113503eed53cd6c53
    10.1093/infdis/jiw187
    Scopus Count
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    Other Diseases

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