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dc.contributor.authorMuehlenbachs, A
dc.contributor.authorde la Rosa Vázquez, O
dc.contributor.authorBausch, DG
dc.contributor.authorSchafer, IJ
dc.contributor.authorPaddock, CD
dc.contributor.authorNyakio, JP
dc.contributor.authorLame, P
dc.contributor.authorBergeron, E
dc.contributor.authorMcCollum, AM
dc.contributor.authorGoldsmith, CS
dc.contributor.authorBollweg, BC
dc.contributor.authorPrieto, MA
dc.contributor.authorLushima, RS
dc.contributor.authorIlunga, BK
dc.contributor.authorNichol, ST
dc.contributor.authorShieh, WJ
dc.contributor.authorStröher, U
dc.contributor.authorRollin, PE
dc.contributor.authorZaki, SR
dc.date.accessioned2017-02-28T22:46:51Z
dc.date.available2017-02-28T22:46:51Z
dc.date.issued2016-05-25en
dc.date.submitted2016-05-31en
dc.identifier.citationEbola virus disease in pregnancy: clinical, histopathologic and immunohistochemical findings. 2016: J. Infect. Dis.en
dc.identifier.issn1537-6613en
dc.identifier.pmid27226206en
dc.identifier.doi10.1093/infdis/jiw206en
dc.identifier.urihttp://hdl.handle.net/10144/618827
dc.description.abstractHere we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibugyo virus had a livebirth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemistry, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malaria pigment-laden macrophages. These data suggest trophoblast infection may be a mechanism of transplacental ebolavirus transmission.
dc.languageENGen
dc.language.isoenen
dc.publisherOxford University Press We regret that this article is behind a paywall.en
dc.titleEbola Virus Disease in Pregnancy: Clinical, Histopathologic and Immunohistochemical Findingsen
dc.identifier.journalJournal of Infectious Diseasesen
dc.internal.reviewer-noteJ Inf Dis - Oxforden
html.description.abstractHere we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibugyo virus had a livebirth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemistry, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malaria pigment-laden macrophages. These data suggest trophoblast infection may be a mechanism of transplacental ebolavirus transmission.


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