Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Beck, Hans Peter
Barry, Clifton E
Kohl, Thomas A
Shamputa, Isdore Chola
MetadataShow full item record
AbstractMycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
- Early ancient sublineages of Mycobacterium tuberculosis Beijing genotype: unexpected clues from phylogenomics of the pathogen and human history.
- Authors: Mokrousov I, Vyazovaya A, Pasechnik O, Gerasimova A, Dymova M, Chernyaeva E, Tatarintseva M, Stasenko V
- Issue date: 2019 Aug
- Drug resistant Mycobacterium tuberculosis of the Beijing genotype does not spread in Sweden.
- Authors: Ghebremichael S, Groenheit R, Pennhag A, Koivula T, Andersson E, Bruchfeld J, Hoffner S, Romanus V, Källenius G
- Issue date: 2010 May 28
- Mycobacterium tuberculosis Beijing lineage favors the spread of multidrug-resistant tuberculosis in the Republic of Georgia.
- Authors: Niemann S, Diel R, Khechinashvili G, Gegia M, Mdivani N, Tang YW
- Issue date: 2010 Oct
- Comparison of the socio-demographic and clinical features of pulmonary TB patients infected with sub-lineages within the W-Beijing and non-Beijing Mycobacterium tuberculosis.
- Authors: Hu Y, Mathema B, Zhao Q, Zheng X, Li D, Jiang W, Wang W, Xu B
- Issue date: 2016 Mar
- Tuberculosis - A global emergency: Tools and methods to monitor, understand, and control the epidemic with specific example of the Beijing lineage.
- Authors: Couvin D, Rastogi N
- Issue date: 2015 Jun