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    Jan 17, 2021
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    Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

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    Name:
    Merker M et al - 2015 - Evolut ...
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    Authors
    Merker, Matthias
    Blin, Camille
    Mona, Stefano
    Duforet-Frebourg, Nicolas
    Lecher, Sophie
    Willery, Eve
    Blum, Michael
    Rüsch-Gerdes, Sabine
    Mokrousov, Igor
    Aleksic, Eman
    Allix-Béguec, Caroline
    Antierens, Annick
    Augustynowicz-Kopeć, Ewa
    Ballif, Marie
    Barletta, Francesca
    Beck, Hans Peter
    Barry, Clifton E
    Bonnet, Maryline
    Borroni, Emanuele
    Campos-Herrero, Isolina
    Cirillo, Daniela
    Cox, Helen
    Crowe, Suzanne
    Crudu, Valeriu
    Diel, Roland
    Drobniewski, Francis
    Fauville-Dufaux, Maryse
    Gagneux, Sébastien
    Ghebremichael, Solomon
    Hanekom, Madeleine
    Hoffner, Sven
    Jiao, Wei-Wei
    Kalon, Stobdan
    Kohl, Thomas A
    Kontsevaya, Irina
    Lillebæk, Troels
    Maeda, Shinji
    Nikolayevskyy, Vladyslav
    Rasmussen, Michael
    Rastogi, Nalin
    Samper, Sofia
    Sanchez-Padilla, Elisabeth
    Savic, Branislava
    Shamputa, Isdore Chola
    Shen, Adong
    Sng, Li-Hwei
    Stakenas, Petras
    Toit, Kadri
    Varaine, Francis
    Vukovic, Dragana
    Wahl, Céline
    Warren, Robin
    Supply, Philip
    Niemann, Stefan
    Wirth, Thierry
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    Issue Date
    2015-01-19
    
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    Journal
    Nature Genetics
    Abstract
    Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
    Publisher
    Nature Publishing Group - We regret that this article is behind a paywall.
    URI
    http://hdl.handle.net/10144/618867
    DOI
    10.1038/ng.3195
    PubMed ID
    25599400
    Language
    en
    ISSN
    1546-1718
    ae974a485f413a2113503eed53cd6c53
    10.1038/ng.3195
    Scopus Count
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    TB

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