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dc.contributor.authorMerker, Matthias
dc.contributor.authorBlin, Camille
dc.contributor.authorMona, Stefano
dc.contributor.authorDuforet-Frebourg, Nicolas
dc.contributor.authorLecher, Sophie
dc.contributor.authorWillery, Eve
dc.contributor.authorBlum, Michael
dc.contributor.authorRüsch-Gerdes, Sabine
dc.contributor.authorMokrousov, Igor
dc.contributor.authorAleksic, Eman
dc.contributor.authorAllix-Béguec, Caroline
dc.contributor.authorAntierens, Annick
dc.contributor.authorAugustynowicz-Kopeć, Ewa
dc.contributor.authorBallif, Marie
dc.contributor.authorBarletta, Francesca
dc.contributor.authorBeck, Hans Peter
dc.contributor.authorBarry, Clifton E
dc.contributor.authorBonnet, Maryline
dc.contributor.authorBorroni, Emanuele
dc.contributor.authorCampos-Herrero, Isolina
dc.contributor.authorCirillo, Daniela
dc.contributor.authorCox, Helen
dc.contributor.authorCrowe, Suzanne
dc.contributor.authorCrudu, Valeriu
dc.contributor.authorDiel, Roland
dc.contributor.authorDrobniewski, Francis
dc.contributor.authorFauville-Dufaux, Maryse
dc.contributor.authorGagneux, Sébastien
dc.contributor.authorGhebremichael, Solomon
dc.contributor.authorHanekom, Madeleine
dc.contributor.authorHoffner, Sven
dc.contributor.authorJiao, Wei-Wei
dc.contributor.authorKalon, Stobdan
dc.contributor.authorKohl, Thomas A
dc.contributor.authorKontsevaya, Irina
dc.contributor.authorLillebæk, Troels
dc.contributor.authorMaeda, Shinji
dc.contributor.authorNikolayevskyy, Vladyslav
dc.contributor.authorRasmussen, Michael
dc.contributor.authorRastogi, Nalin
dc.contributor.authorSamper, Sofia
dc.contributor.authorSanchez-Padilla, Elisabeth
dc.contributor.authorSavic, Branislava
dc.contributor.authorShamputa, Isdore Chola
dc.contributor.authorShen, Adong
dc.contributor.authorSng, Li-Hwei
dc.contributor.authorStakenas, Petras
dc.contributor.authorToit, Kadri
dc.contributor.authorVaraine, Francis
dc.contributor.authorVukovic, Dragana
dc.contributor.authorWahl, Céline
dc.contributor.authorWarren, Robin
dc.contributor.authorSupply, Philip
dc.contributor.authorNiemann, Stefan
dc.contributor.authorWirth, Thierry
dc.date.accessioned2017-03-21T16:45:20Z
dc.date.available2017-03-21T16:45:20Z
dc.date.issued2015-01-19
dc.identifier.citationEvolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. 2015: Nat. Genet.en
dc.identifier.issn1546-1718
dc.identifier.pmid25599400
dc.identifier.doi10.1038/ng.3195
dc.identifier.urihttp://hdl.handle.net/10144/618867
dc.description.abstractMycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
dc.languageENG
dc.language.isoenen
dc.publisherNature Publishing Group - We regret that this article is behind a paywall.en
dc.titleEvolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineageen
dc.identifier.journalNature Geneticsen
dc.internal.reviewer-noteNature Genetics - low prriority Paywallen
refterms.dateFOA2019-03-04T13:15:08Z
html.description.abstractMycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.


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