Journal
PLoS Neglected Tropical DiseasesAbstract
The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.Publisher
Public Library of SciencePubMed ID
28328984Language
enISSN
1935-2735ae974a485f413a2113503eed53cd6c53
10.1371/journal.pntd.0005470