Mycobacterium Tuberculosis Lineage 4 Comprises Globally Distributed and Geographically Restricted Sublineages
Authors
Stucki, DBrites, D
Jeljeli, L
Coscolla, M
Liu, Q
Trauner, A
Fenner, L
Rutaihwa, L
Borrell, S
Luo, T
Gao, Q
Kato-Maeda, M
Ballif, M
Egger, M
Macedo, R
Mardassi, H
Moreno, M
Vilanova, GT
Fyfe, J
Globan, M
Thomas, J
Jamieson, F
Guthrie, JL
Asante-Poku, A
Yeboah-Manu, D
Wampande, E
Ssengooba, W
Joloba, M
Boom, WH
Basu, I
Bower, J
Saraiva, M
Vasconcellos, SEG
Suffys, P
Koch, A
Wilkinson, R
Gail-Bekker, L
Malla, B
Ley, SD
Beck, HP
de Jong, Bouke C
Toit, K
Sanchez-Padilla, E
Bonnet, M
Gil-Brusola, A
Frank, M
Penlap Beng, VN
Eisenach, K
Alani, I
Ndung'u, PW
Revathi, G
Gehre, F
Akter, S
Ntoumi, F
Stewart-Isherwood, L
Ntinginya, NE
Rachow, A
Hoelscher, M
Cirillo, DM
Skenders, G
Hoffner, S
Bakonyte, D
Stakenas, P
Diel, R
Crudu, V
Moldovan, O
Al-Hajoj, S
Otero, L
Barletta, F
Carter, EJ
Diero, L
Supply, P
Comas, I
Niemann, S
Gagneux, S
Issue Date
2016-12-01Submitted date
2017-05-24
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Nature GeneticsAbstract
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.Publisher
Nature Publishing GroupDOI
10.1038/ng.3704PubMed ID
27798628Language
enISSN
1546-1718ae974a485f413a2113503eed53cd6c53
10.1038/ng.3704
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