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    Jan 19, 2021
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    Mycobacterium Tuberculosis Lineage 4 Comprises Globally Distributed and Geographically Restricted Sublineages

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    Authors
    Stucki, D
    Brites, D
    Jeljeli, L
    Coscolla, M
    Liu, Q
    Trauner, A
    Fenner, L
    Rutaihwa, L
    Borrell, S
    Luo, T
    Gao, Q
    Kato-Maeda, M
    Ballif, M
    Egger, M
    Macedo, R
    Mardassi, H
    Moreno, M
    Vilanova, GT
    Fyfe, J
    Globan, M
    Thomas, J
    Jamieson, F
    Guthrie, JL
    Asante-Poku, A
    Yeboah-Manu, D
    Wampande, E
    Ssengooba, W
    Joloba, M
    Boom, WH
    Basu, I
    Bower, J
    Saraiva, M
    Vasconcellos, SEG
    Suffys, P
    Koch, A
    Wilkinson, R
    Gail-Bekker, L
    Malla, B
    Ley, SD
    Beck, HP
    de Jong, Bouke C
    Toit, K
    Sanchez-Padilla, E
    Bonnet, M
    Gil-Brusola, A
    Frank, M
    Penlap Beng, VN
    Eisenach, K
    Alani, I
    Ndung'u, PW
    Revathi, G
    Gehre, F
    Akter, S
    Ntoumi, F
    Stewart-Isherwood, L
    Ntinginya, NE
    Rachow, A
    Hoelscher, M
    Cirillo, DM
    Skenders, G
    Hoffner, S
    Bakonyte, D
    Stakenas, P
    Diel, R
    Crudu, V
    Moldovan, O
    Al-Hajoj, S
    Otero, L
    Barletta, F
    Carter, EJ
    Diero, L
    Supply, P
    Comas, I
    Niemann, S
    Gagneux, S
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    Issue Date
    2016-12-01
    Submitted date
    2017-05-24
    
    Metadata
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    Journal
    Nature Genetics
    Abstract
    Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
    Publisher
    Nature Publishing Group
    URI
    http://hdl.handle.net/10144/618917
    DOI
    10.1038/ng.3704
    PubMed ID
    27798628
    Language
    en
    ISSN
    1546-1718
    ae974a485f413a2113503eed53cd6c53
    10.1038/ng.3704
    Scopus Count
    Collections
    TB

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