Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda
Boum Ii, Y
MetadataShow full item record
AbstractInfections of the central nervous system (CNS) are severe conditions, leading to neurological sequelae or death. Knowledge of the causative agents is essential to develop guidelines for case management in resource-limited settings. Between August 2009 and October 2012, we conducted a prospective descriptive study of the aetiology of suspected CNS infections in children two months to 12 years old, with fever and at least one sign of CNS involvement in Mbarara Hospital, Uganda. Children were clinically evaluated on admission and discharge, and followed-up for 6 months for neurological sequelae. Pathogens were identified from cerebrospinal fluid (CSF) and blood using microbiological and molecular methods. We enrolled 459 children. Plasmodium falciparum (36.2%) and bacteria in CSF (13.3%) or blood (3.3%) were the most detected pathogens. Viruses were found in 27 (5.9%) children. No pathogen was isolated in 207 (45.1%) children. Patterns varied by age and HIV status. Eighty-three (18.1%) children died during hospitalisation, and 23 (5.0%) during follow-up. Forty-one (13.5%) children had neurological sequelae at the last visit. While malaria remains the main aetiology in children with suspected CNS infections, no pathogen was isolated in many children. The high mortality and high rate of neurological sequelae highlight the need for efficient diagnosis.
PublisherNature Publishing Group
- Viral CNS infections in children from a malaria-endemic area of Malawi: a prospective cohort study.
- Authors: Mallewa M, Vallely P, Faragher B, Banda D, Klapper P, Mukaka M, Khofi H, Pensulo P, Taylor T, Molyneux M, Solomon T
- Issue date: 2013 Sep
- The aetiologies of central nervous system infections in hospitalised Cambodian children.
- Authors: Turner P, Suy K, Tan LV, Sar P, Miliya T, Hong NTT, Hang VTT, Ny NTH, Soeng S, Day NPJ, van Doorn HR, Turner C
- Issue date: 2017 Dec 29
- Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study.
- Authors: Ho Dang Trung N, Le Thi Phuong T, Wolbers M, Nguyen Van Minh H, Nguyen Thanh V, Van MP, Thieu NT, Van TL, Song DT, Thi PL, Thi Phuong TN, Van CB, Tang V, Ngoc Anh TH, Nguyen D, Trung TP, Thi Nam LN, Kiem HT, Thi Thanh TN, Campbell J, Caws M, Day J, de Jong MD, Van Vinh CN, Van Doorn HR, Tinh HT, Farrar J, Schultsz C, VIZIONS CNS Infection Network.
- Issue date: 2012
- Human parechovirus type 3 central nervous system infections in Israeli infants.
- Authors: Ghanem-Zoubi N, Shiner M, Shulman LM, Sofer D, Wolf D, Marva E, Kra-Oz Z, Shachor-Meyouhas Y, Averbuch D, Bechor-Fellner A, Barkai G, Kinarty A, Gershstein V, Ephros M
- Issue date: 2013 Sep
- Comorbidities and factors associated with central nervous system infections and death in non-perinatal listeriosis: a clinical case series.
- Authors: Maertens De Noordhout C, Devleesschauwer B, Maertens De Noordhout A, Blocher J, Haagsma JA, Havelaar AH, Speybroeck N
- Issue date: 2016 Jun 7