Ciprofloxacin for Contacts of Cases of Meningococcal Meningitis as an Epidemic Response: Study Protocol for a Cluster-Randomized Trial
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AbstractEpidemics of meningococcal meningitis are common in the "African meningitis belt." Current response strategies include reactive vaccination campaigns, which are often organized too late to have maximal impact. A novel strain of Neisseria meningitidis serogroup C has been circulating in recent years, and vaccine supplies are limited. An evaluation of chemoprophylaxis with single-dose ciprofloxacin for household contacts of meningitis cases has therefore been recommended.