Protection Against Cholera From Killed Whole-Cell Oral Cholera Vaccines: A Systematic Review and Meta-Analysis
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JournalThe Lancet Infectious Diseases
AbstractKilled whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges for public health decision making. We did a systematic review and meta-analysis to generate average estimates of kOCV efficacy and direct effectiveness from the available literature.