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    Mar 03, 2021
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    Deuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutrition

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    Authors
    Fabiansen, C
    Yaméogo, CW
    Devi, S
    Friis, H
    Kurpad, A
    Wells, JC
    Issue Date
    2017-03-03
    Submitted date
    2017-03-15
    
    Metadata
    Show full item record
    Journal
    Isotopes in Environmental and Health Studies
    Abstract
    Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.
    Publisher
    Taylor and Francis
    URI
    http://hdl.handle.net/10144/619013
    DOI
    10.1080/10256016.2017.1295043
    PubMed ID
    28276731
    Additional Links
    http://www.tandfonline.com/doi/abs/10.1080/10256016.2017.1295043
    Language
    en
    Description
    Abstract available only. Full article is not Open Access. We regret that this article is behind a paywall.
    ISSN
    1477-2639
    ae974a485f413a2113503eed53cd6c53
    10.1080/10256016.2017.1295043
    Scopus Count
    Collections
    Paediatrics

    entitlement

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