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dc.contributor.authorFabiansen, C
dc.contributor.authorYaméogo, CW
dc.contributor.authorDevi, S
dc.contributor.authorFriis, H
dc.contributor.authorKurpad, A
dc.contributor.authorWells, JC
dc.date.accessioned2017-09-07T13:52:46Z
dc.date.available2017-09-07T13:52:46Z
dc.date.issued2017-03-03
dc.date.submitted2017-03-15
dc.identifier.citationDeuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutrition. 2017:1-12 Isotopes Environ Health Studen
dc.identifier.issn1477-2639
dc.identifier.pmid28276731
dc.identifier.doi10.1080/10256016.2017.1295043
dc.identifier.urihttp://hdl.handle.net/10144/619013
dc.descriptionAbstract available only. Full article is not Open Access. We regret that this article is behind a paywall.en
dc.description.abstractChildhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.
dc.language.isoenen
dc.publisherTaylor and Francisen
dc.relation.urlhttp://www.tandfonline.com/doi/abs/10.1080/10256016.2017.1295043en
dc.titleDeuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutritionen
dc.identifier.journalIsotopes in Environmental and Health Studiesen
dc.internal.reviewer-noteWait for publication - may be OAen
html.description.abstractChildhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.


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