Long-term Clinical Outcomes in Visceral Leishmaniasis-HIV Co-infected Patients during and after Pentamidine Secondary Prophylaxis in Ethiopia: a single-arm clinical trial

Diro, E; Ritmeijer, K; Boelaert, M; Alves, F; Mohammed, R; Abongomera, C; Ravinetto, R; De Crop, M; Fikre, H; Adera, C; van Loen, H; Tsoumanis, A; Adriaensen, W; Hailu, A; van Griensven, J

dc.contributor.author	Diro, E
dc.contributor.author	Ritmeijer, K
dc.contributor.author	Boelaert, M
dc.contributor.author	Alves, F
dc.contributor.author	Mohammed, R
dc.contributor.author	Abongomera, C
dc.contributor.author	Ravinetto, R
dc.contributor.author	De Crop, M
dc.contributor.author	Fikre, H
dc.contributor.author	Adera, C
dc.contributor.author	van Loen, H
dc.contributor.author	Tsoumanis, A
dc.contributor.author	Adriaensen, W
dc.contributor.author	Hailu, A
dc.contributor.author	van Griensven, J
dc.date.accessioned	2017-10-24T14:00:30Z
dc.date.available	2017-10-24T14:00:30Z
dc.date.issued	2017-09-13
dc.date.submitted	2017-10-18
dc.identifier.citation	Long-term Clinical Outcomes in Visceral Leishmaniasis-HIV Co-infected Patients during and after Pentamidine Secondary Prophylaxis in Ethiopia: a single-arm clinical trial. 2017 Clin. Infect. Dis.	en
dc.identifier.issn	1537-6591
dc.identifier.pmid	29020217
dc.identifier.doi	10.1093/cid/cix807
dc.identifier.uri	http://hdl.handle.net/10144/619029
dc.description.abstract	We have conducted a single-arm trial evaluating monthly pentamidine secondary prophylaxis (PSP) to prevent visceral leishmaniasis (VL) relapse in Ethiopian HIV-patients. Outcomes at 12 months of PSP have been previously reported, supporting PSP effectiveness and safety. However, remaining relapse-free after PSP discontinuation is vital. We now report outcomes and associated factors for a period of upto 2.5 years after initiating PSP, including one year follow-up after PSP discontinuation.
dc.language.iso	en	en
dc.publisher	Oxford University Press	en
dc.rights	Archived with thanks to Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America	en
dc.title	Long-term Clinical Outcomes in Visceral Leishmaniasis-HIV Co-infected Patients during and after Pentamidine Secondary Prophylaxis in Ethiopia: a single-arm clinical trial	en
dc.identifier.journal	Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America	en
refterms.dateFOA	2019-03-04T13:38:23Z
html.description.abstract	We have conducted a single-arm trial evaluating monthly pentamidine secondary prophylaxis (PSP) to prevent visceral leishmaniasis (VL) relapse in Ethiopian HIV-patients. Outcomes at 12 months of PSP have been previously reported, supporting PSP effectiveness and safety. However, remaining relapse-free after PSP discontinuation is vital. We now report outcomes and associated factors for a period of upto 2.5 years after initiating PSP, including one year follow-up after PSP discontinuation.