A Novel Electronic Algorithm using Host Biomarker Point-of-Care tests for the Management of Febrile Illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial
Authors
Keitel, KKagoro, F
Samaka, J
Masimba, J
Said, Z
Temba, H
Mlaganile, T
Sangu, W
Rambaud-Althaus, C
Gervaix, A
Genton, B
D'Acremont, V
Issue Date
2017-10-23Submitted date
2017-11-06
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PLoS MedicineAbstract
The management of childhood infections remains inadequate in resource-limited countries, resulting in high mortality and irrational use of antimicrobials. Current disease management tools, such as the Integrated Management of Childhood Illness (IMCI) algorithm, rely solely on clinical signs and have not made use of available point-of-care tests (POCTs) that can help to identify children with severe infections and children in need of antibiotic treatment. e-POCT is a novel electronic algorithm based on current evidence; it guides clinicians through the entire consultation and recommends treatment based on a few clinical signs and POCT results, some performed in all patients (malaria rapid diagnostic test, hemoglobin, oximeter) and others in selected subgroups only (C-reactive protein, procalcitonin, glucometer). The objective of this trial was to determine whether the clinical outcome of febrile children managed by the e-POCT tool was non-inferior to that of febrile children managed by a validated electronic algorithm derived from IMCI (ALMANACH), while reducing the proportion with antibiotic prescription.Publisher
Public Library of SciencePubMed ID
29059253Language
enISSN
1549-1676ae974a485f413a2113503eed53cd6c53
10.1371/journal.pmed.1002411
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