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    Jan 20, 2021
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    Immunogenicity and Protection from a Single Dose of Internationally available killed oral Cholera Vaccine: a systematic review and meta-analysis

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    2017 Lopez AL Immunogenicity and ...
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    Authors
    Lopez, AL
    Deen, J
    Azman, AS
    Luquero, FJ
    Kanungo, S
    Dutta, S
    von Seidlein, L
    Sack, DA
    Issue Date
    2017-11-21
    Submitted date
    2017-12-15
    
    Metadata
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    Journal
    Clinical Infectious Diseases
    Abstract
    In addition to improved water supply and sanitation, the two-dose killed oral cholera vaccine (OCV) is an important tool for the prevention and control of cholera. We aimed to document the immunogenicity and protection (efficacy and effectiveness) conferred by a single OCV dose against cholera. The meta-analysis showed an estimated 73% and 77% of individuals seroconverted to the Ogawa and Inaba serotypes, respectively, after an OCV first dose. The estimates of single-dose vaccine protection from available studies are 87% at 2 months decreasing to 33% at 2 years. Current immunologic and clinical data suggest that protection conferred by a single dose of killed OCV may be sufficient to reduce short-term risk in outbreaks or other high-risk settings, which may be especially useful when vaccine supply is limited. However, until more data suggests otherwise, a second dose should be given as soon as circumstances allow to ensure robust protection.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/619049
    DOI
    10.1093/cid/cix1039
    PubMed ID
    29177437
    Language
    en
    ISSN
    1537-6591
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/cix1039
    Scopus Count
    Collections
    Vaccination

    entitlement

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