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    Mar 02, 2021
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    Genomic History of the seventh Pandemic of Cholera in Africa

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    2017 Weill FX Genomic history ...
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    Authors
    Weill, FX
    Domman, D
    Njamkepo, E
    Tarr, C
    Rauzier, J
    Fawal, N
    Keddy, KH
    Salje, H
    Moore, S
    Mukhopadhyay, AK
    Bercion, R
    Luquero, FJ
    Ngandjio, A
    Dosso, M
    Monakhova, E
    Garin, B
    Bouchier, C
    Pazzani, C
    Mutreja, A
    Grunow, R
    Sidikou, F
    Bonte, L
    Breurec, S
    Damian, M
    Njanpop-Lafourcade, BM
    Sapriel, G
    Page, AL
    Hamze, M
    Henkens, M
    Chowdhury, G
    Mengel, M
    Koeck, JL
    Fournier, JM
    Dougan, G
    Grimont, PAD
    Parkhill, J
    Holt, KE
    Piarroux, R
    Ramamurthy, T
    Quilici, ML
    Thomson, NR
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    Issue Date
    2017-11-10
    Submitted date
    2017-12-13
    
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    Journal
    Science (New York, N.Y.)
    Abstract
    The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.
    Publisher
    American Association for the Advancement of Science
    URI
    http://hdl.handle.net/10144/619052
    DOI
    10.1126/science.aad5901
    PubMed ID
    29123067
    Language
    en
    ISSN
    1095-9203
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.aad5901
    Scopus Count
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