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dc.contributor.authorWeill, FX
dc.contributor.authorDomman, D
dc.contributor.authorNjamkepo, E
dc.contributor.authorTarr, C
dc.contributor.authorRauzier, J
dc.contributor.authorFawal, N
dc.contributor.authorKeddy, KH
dc.contributor.authorSalje, H
dc.contributor.authorMoore, S
dc.contributor.authorMukhopadhyay, AK
dc.contributor.authorBercion, R
dc.contributor.authorLuquero, FJ
dc.contributor.authorNgandjio, A
dc.contributor.authorDosso, M
dc.contributor.authorMonakhova, E
dc.contributor.authorGarin, B
dc.contributor.authorBouchier, C
dc.contributor.authorPazzani, C
dc.contributor.authorMutreja, A
dc.contributor.authorGrunow, R
dc.contributor.authorSidikou, F
dc.contributor.authorBonte, L
dc.contributor.authorBreurec, S
dc.contributor.authorDamian, M
dc.contributor.authorNjanpop-Lafourcade, BM
dc.contributor.authorSapriel, G
dc.contributor.authorPage, AL
dc.contributor.authorHamze, M
dc.contributor.authorHenkens, M
dc.contributor.authorChowdhury, G
dc.contributor.authorMengel, M
dc.contributor.authorKoeck, JL
dc.contributor.authorFournier, JM
dc.contributor.authorDougan, G
dc.contributor.authorGrimont, PAD
dc.contributor.authorParkhill, J
dc.contributor.authorHolt, KE
dc.contributor.authorPiarroux, R
dc.contributor.authorRamamurthy, T
dc.contributor.authorQuilici, ML
dc.contributor.authorThomson, NR
dc.date.accessioned2017-12-20T23:58:08Z
dc.date.available2017-12-20T23:58:08Z
dc.date.issued2017-11-10
dc.date.submitted2017-12-13
dc.identifier.citationGenomic History of the seventh Pandemic of Cholera in Africa. 2017, 358 (6364):785-789 Scienceen
dc.identifier.issn1095-9203
dc.identifier.pmid29123067
dc.identifier.doi10.1126/science.aad5901
dc.identifier.urihttp://hdl.handle.net/10144/619052
dc.description.abstractThe seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.rightsArchived with thanks to Science (New York, N.Y.)en
dc.titleGenomic History of the seventh Pandemic of Cholera in Africaen
dc.identifier.journalScience (New York, N.Y.)en
refterms.dateFOA2019-03-04T13:40:25Z
html.description.abstractThe seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.


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