Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa
Authors
Taylor, WRNaw, HK
Maitland, K
Williams, TN
Kapulu, M
D'Alessandro, U
Berkley, JA
Bejon, P
Okebe, J
Achan, J
Amambua, AN
Affara, M
Nwakanma, D
van Geertruyden, JP
Mavoko, M
Lutumba, P
Matangila, J
Brasseur, P
Piola, P
Randremanana, R
Lasry, E
Fanello, C
Onyamboko, M
Schramm, B
Yah, Z
Jones, J
Fairhurst, RM
Diakite, M
Malenga, G
Molyneux, M
Rwagacondo, C
Obonyo, C
Gadisa, E
Aseffa, A
Loolpapit, M
Henry, MC
Dorsey, G
John, C
Sirima, SB
Barnes, KI
Kremsner, P
Day, NP
White, NJ
Mukaka, M
Issue Date
2018-01-18Submitted date
2018-01-25
Metadata
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BMC MedicineAbstract
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa.Publisher
BioMed CentralPubMed ID
29347975Language
enISSN
1741-7015ae974a485f413a2113503eed53cd6c53
10.1186/s12916-017-0990-6
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