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    Apr 19, 2021
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    Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

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    Authors
    Taylor, WR
    Naw, HK
    Maitland, K
    Williams, TN
    Kapulu, M
    D'Alessandro, U
    Berkley, JA
    Bejon, P
    Okebe, J
    Achan, J
    Amambua, AN
    Affara, M
    Nwakanma, D
    van Geertruyden, JP
    Mavoko, M
    Lutumba, P
    Matangila, J
    Brasseur, P
    Piola, P
    Randremanana, R
    Lasry, E
    Fanello, C
    Onyamboko, M
    Schramm, B
    Yah, Z
    Jones, J
    Fairhurst, RM
    Diakite, M
    Malenga, G
    Molyneux, M
    Rwagacondo, C
    Obonyo, C
    Gadisa, E
    Aseffa, A
    Loolpapit, M
    Henry, MC
    Dorsey, G
    John, C
    Sirima, SB
    Barnes, KI
    Kremsner, P
    Day, NP
    White, NJ
    Mukaka, M
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    Issue Date
    2018-01-18
    Submitted date
    2018-01-25
    
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    Journal
    BMC Medicine
    Abstract
    In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa.
    Publisher
    BioMed Central
    URI
    http://hdl.handle.net/10144/619061
    DOI
    10.1186/s12916-017-0990-6
    PubMed ID
    29347975
    Language
    en
    ISSN
    1741-7015
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12916-017-0990-6
    Scopus Count
    Collections
    Malaria

    entitlement

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