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    Jan 16, 2021
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    Precision medicine for drug-resistant tuberculosis in high-burden countries: is individualised treatment desirable and feasible?

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    Cox et al - 2018 - Precision ...
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    Authors
    Cox, H
    Hughes, J
    Black, J
    Nicol, MP
    Issue Date
    2018-03-13
    Submitted date
    2018-04-17
    
    Metadata
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    Journal
    The Lancet. Infectious Diseases
    Abstract
    Treatment for drug-resistant tuberculosis is largely delivered through standardised, empirical combination regimens in low-resource, high-burden settings. However, individualised treatment, guided by detailed drug susceptibility testing, probably results in improved individual outcomes and is the standard of care in well-resourced settings. Driven by the urgent need to scale up treatment provision, new tuberculosis drugs, incorporated into standardised regimens, are being tested. Although standardised regimens are expected to improve access to treatment in high-burden settings, they are also likely to contribute to the emergence of resistance, even with good clinical management. We argue that a balance is required between the need to improve treatment access and the imperative to minimise resistance amplification and provide the highest standard of care, through a precision medicine approach. In tuberculosis, as in other diseases, we should aim to reduce the entrenched inequalities that manifest as different standards of care in different settings.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/619094
    DOI
    10.1016/S1473-3099(18)30104-X
    PubMed ID
    29548923
    Language
    en
    ISSN
    1474-4457
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1473-3099(18)30104-X
    Scopus Count
    Collections
    TB

    entitlement

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