Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger
Authors
Grais, RFLaminou, IM
Woi-Messe, L
Makarimi, R
Bouriema, SH
Langendorf, C
Amambua-Ngwa, A
D'Alessandro, U
Guérin, PJ
Fandeur, T
Sibley, CH
Issue Date
2018-02-27Submitted date
2018-04-17
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Malaria JournalAbstract
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine-pyrimethamine (AQ + SP) is recommended in the country to be administered monthly just before and during the rainy season. Moreover, clinical decisions on use of SP for intermittent preventive treatment in pregnancy (IPTp) now depend upon the validated molecular markers for SP resistance in Plasmodium falciparum observed in the local parasite population. However, little is known about molecular markers of resistance for either SP or AQ in the south of Niger. To address this question, clinical samples which met clinical and biological criteria, were collected in Gabi, Madarounfa district, Maradi region, Niger in 2011-2012 (before SMC implementation). Molecular markers of resistance to pyrimethamine (pfdhfr), sulfadoxine (pfdhps) and amodiaquine (pfmdr1) were assessed by DNA sequencing.Publisher
BioMed CentralPubMed ID
29486766Language
enISSN
1475-2875ae974a485f413a2113503eed53cd6c53
10.1186/s12936-018-2242-4
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