Show simple item record

dc.contributor.authorGignoux, E
dc.contributor.authorPolonsky, J
dc.contributor.authorCiglenecki, I
dc.contributor.authorBichet, M
dc.contributor.authorColdiron, M
dc.contributor.authorThuambe Lwiyo, E
dc.contributor.authorAkonda, I
dc.contributor.authorSerafini, M
dc.contributor.authorPorten, K
dc.date.accessioned2018-05-08T14:13:11Z
dc.date.available2018-05-08T14:13:11Z
dc.date.issued2018-03-14
dc.date.submitted2018-05-03
dc.identifier.citationRisk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013. 2018, 13 (3):e0194276 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid29538437
dc.identifier.doi10.1371/journal.pone.0194276
dc.identifier.urihttp://hdl.handle.net/10144/619113
dc.description.abstractIn 2013, a large measles epidemic occurred in the Aketi Health Zone of the Democratic Republic of Congo. We conducted a two-stage, retrospective cluster survey to estimate the attack rate, the case fatality rate, and the measles-specific mortality rate during the epidemic. 1424 households containing 7880 individuals were included. The estimated attack rate was 14.0%, (35.0% among children aged <5 years). The estimated case fatality rate was 4.2% (6.1% among children aged <5 years). Spatial analysis and linear regression showed that younger children, those who did not receive care, and those living farther away from Aketi Hospital early in the epidemic had a higher risk of measles related death. Vaccination coverage prior to the outbreak was low (76%), and a delayed reactive vaccination campaign contributed to the high attack rate. We provide evidences suggesting that a comprehensive case management approach reduced measles fatality during this epidemic in rural, inaccessible resource-poor setting.
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsPublished by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permissionen
dc.titleRisk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013en
dc.identifier.journalPloS Oneen
refterms.dateFOA2019-03-04T13:52:17Z
html.description.abstractIn 2013, a large measles epidemic occurred in the Aketi Health Zone of the Democratic Republic of Congo. We conducted a two-stage, retrospective cluster survey to estimate the attack rate, the case fatality rate, and the measles-specific mortality rate during the epidemic. 1424 households containing 7880 individuals were included. The estimated attack rate was 14.0%, (35.0% among children aged <5 years). The estimated case fatality rate was 4.2% (6.1% among children aged <5 years). Spatial analysis and linear regression showed that younger children, those who did not receive care, and those living farther away from Aketi Hospital early in the epidemic had a higher risk of measles related death. Vaccination coverage prior to the outbreak was low (76%), and a delayed reactive vaccination campaign contributed to the high attack rate. We provide evidences suggesting that a comprehensive case management approach reduced measles fatality during this epidemic in rural, inaccessible resource-poor setting.


Files in this item

Thumbnail
Name:
Gignoux et al - 2018 - Risk ...
Size:
1.155Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record