Risk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013
| dc.contributor.author | Gignoux, E | |
| dc.contributor.author | Polonsky, J | |
| dc.contributor.author | Ciglenecki, I | |
| dc.contributor.author | Bichet, M | |
| dc.contributor.author | Coldiron, M | |
| dc.contributor.author | Thuambe Lwiyo, E | |
| dc.contributor.author | Akonda, I | |
| dc.contributor.author | Serafini, M | |
| dc.contributor.author | Porten, K | |
| dc.date.accessioned | 2018-05-08T14:13:11Z | |
| dc.date.available | 2018-05-08T14:13:11Z | |
| dc.date.issued | 2018-03-14 | |
| dc.date.submitted | 2018-05-03 | |
| dc.identifier.citation | Risk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013. 2018, 13 (3):e0194276 PLoS ONE | en |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.pmid | 29538437 | |
| dc.identifier.doi | 10.1371/journal.pone.0194276 | |
| dc.identifier.uri | http://hdl.handle.net/10144/619113 | |
| dc.description.abstract | In 2013, a large measles epidemic occurred in the Aketi Health Zone of the Democratic Republic of Congo. We conducted a two-stage, retrospective cluster survey to estimate the attack rate, the case fatality rate, and the measles-specific mortality rate during the epidemic. 1424 households containing 7880 individuals were included. The estimated attack rate was 14.0%, (35.0% among children aged <5 years). The estimated case fatality rate was 4.2% (6.1% among children aged <5 years). Spatial analysis and linear regression showed that younger children, those who did not receive care, and those living farther away from Aketi Hospital early in the epidemic had a higher risk of measles related death. Vaccination coverage prior to the outbreak was low (76%), and a delayed reactive vaccination campaign contributed to the high attack rate. We provide evidences suggesting that a comprehensive case management approach reduced measles fatality during this epidemic in rural, inaccessible resource-poor setting. | |
| dc.language.iso | en | en |
| dc.publisher | Public Library of Science | en |
| dc.rights | Published by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permission | en |
| dc.title | Risk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013 | en |
| dc.identifier.journal | PloS One | en |
| refterms.dateFOA | 2019-03-04T13:52:17Z | |
| html.description.abstract | In 2013, a large measles epidemic occurred in the Aketi Health Zone of the Democratic Republic of Congo. We conducted a two-stage, retrospective cluster survey to estimate the attack rate, the case fatality rate, and the measles-specific mortality rate during the epidemic. 1424 households containing 7880 individuals were included. The estimated attack rate was 14.0%, (35.0% among children aged <5 years). The estimated case fatality rate was 4.2% (6.1% among children aged <5 years). Spatial analysis and linear regression showed that younger children, those who did not receive care, and those living farther away from Aketi Hospital early in the epidemic had a higher risk of measles related death. Vaccination coverage prior to the outbreak was low (76%), and a delayed reactive vaccination campaign contributed to the high attack rate. We provide evidences suggesting that a comprehensive case management approach reduced measles fatality during this epidemic in rural, inaccessible resource-poor setting. |
