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dc.contributor.authorRick, F
dc.contributor.authorNiyibizi, AA
dc.contributor.authorShroufi, A
dc.contributor.authorOnami, K
dc.contributor.authorSteele, SJ
dc.contributor.authorKuleile, M
dc.contributor.authorMuleya, I
dc.contributor.authorChiller, T
dc.contributor.authorWalker, T
dc.contributor.authorVan Cutsem, G
dc.date.accessioned2018-05-17T14:18:58Z
dc.date.available2018-05-17T14:18:58Z
dc.date.issued2017-09-06
dc.date.submitted2018-05-16
dc.identifier.citationCryptococcal antigen screening by lay cadres using a rapid test at the point of care: A feasibility study in rural Lesotho. 2017, 12 (9):e0183656 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid28877182
dc.identifier.doi10.1371/journal.pone.0183656
dc.identifier.urihttp://hdl.handle.net/10144/619134
dc.description.abstractCryptococcal meningitis is one of the leading causes of death among people with HIV in Africa, primarily due to delayed presentation, poor availability and high cost of treatment. Routine cryptococcal antigen (CrAg) screening of patients with a CD4 count less than 100 cells/mm3, followed by pre-emptive therapy if positive, might reduce mortality in high prevalence settings. Using the cryptococcal antigen (CrAg) lateral flow assay (LFA), screening is possible at the point of care (POC). However, critical shortages of health staff may limit adoption. This study investigates the feasibility of lay counsellors conducting CrAg LFA screening in rural primary care clinics in Lesotho.
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsPublished by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permissionen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAlgorithmsen
dc.subject.meshAntigens, Fungalen
dc.subject.meshFeasibility Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshLesothoen
dc.subject.meshMaleen
dc.subject.meshMeningitis, Cryptococcalen
dc.subject.meshMiddle Ageden
dc.subject.meshPoint-of-Care Systemsen
dc.subject.meshRheologyen
dc.subject.meshRural Populationen
dc.subject.meshTreatment Outcomeen
dc.subject.meshYoung Adulten
dc.titleCryptococcal antigen screening by lay cadres using a rapid test at the point of care: A feasibility study in rural Lesothoen
dc.identifier.journalPLoS ONEen
refterms.dateFOA2019-03-04T13:54:24Z
html.description.abstractCryptococcal meningitis is one of the leading causes of death among people with HIV in Africa, primarily due to delayed presentation, poor availability and high cost of treatment. Routine cryptococcal antigen (CrAg) screening of patients with a CD4 count less than 100 cells/mm3, followed by pre-emptive therapy if positive, might reduce mortality in high prevalence settings. Using the cryptococcal antigen (CrAg) lateral flow assay (LFA), screening is possible at the point of care (POC). However, critical shortages of health staff may limit adoption. This study investigates the feasibility of lay counsellors conducting CrAg LFA screening in rural primary care clinics in Lesotho.


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