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    Apr 23, 2021
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    The devil we know: is the use of injectable agents for the treatment of MDR-TB justified?

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    Name:
    Reuter et al - 2017 - The devil ...
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    Authors
    Reuter, A
    Tisile, P
    von Delft, D
    Cox, H
    Cox, V
    Ditiu, L
    Garcia-Prats, A
    Koenig, S
    Lessem, E
    Nathavitharana, R
    Seddon, JA
    Stillo, J
    von Delft, A
    Furin, J
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    Issue Date
    2017-11-01
    Submitted date
    2018-05-16
    
    Metadata
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    Journal
    The International Journal of Tuberculosis and Lung Disease
    Abstract
    For decades, second-line injectable agents (IAs) have been the cornerstone of treatment for multidrug-resistant tuberculosis (MDR-TB). Although evidence on the efficacy of IAs is limited, there is an expanding body of evidence on the serious adverse events caused by these drugs. Here, we present the results of a structured literature review of the safety and efficacy of IAs. We review the continued widespread use of these agents in the context of therapeutic alternatives-most notably the newer TB drugs, bedaquiline and delamanid-and from the context of human rights, ethics and patient-centered care. We conclude that there is limited evidence of the efficacy of IAs, clear evidence of the risks of these drugs, and that persons living with MDR-TB should be informed about these risks and provided with access to alternative therapeutic options.
    Publisher
    International Union Against Tuberculosis and Lung Disease
    URI
    http://hdl.handle.net/10144/619139
    DOI
    10.5588/ijtld.17.0468
    PubMed ID
    29037291
    Language
    en
    ISSN
    1815-7920
    ae974a485f413a2113503eed53cd6c53
    10.5588/ijtld.17.0468
    Scopus Count
    Collections
    TB

    entitlement

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