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    Mar 02, 2021
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    New insights into leishmaniasis in the immunosuppressed

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    Name:
    Akuffo et al - 2018 - New insights ...
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    Authors
    Akuffo, H
    Costa, C
    van Griensven, J
    Burza, S
    Moreno, J
    Herrero, M
    Issue Date
    2018-05-10
    Submitted date
    2018-05-18
    
    Metadata
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    Journal
    PLoS Neglected Tropical Diseases
    Abstract
    Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas.
    Publisher
    Public Library of Science
    URI
    http://hdl.handle.net/10144/619163
    DOI
    10.1371/journal.pntd.0006375
    PubMed ID
    29746470
    Language
    en
    ISSN
    1935-2735
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pntd.0006375
    Scopus Count
    Collections
    Leishmaniasis/Kala Azar

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