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dc.contributor.authorAkuffo, H
dc.contributor.authorCosta, C
dc.contributor.authorvan Griensven, J
dc.contributor.authorBurza, S
dc.contributor.authorMoreno, J
dc.contributor.authorHerrero, M
dc.date.accessioned2018-05-22T14:58:45Z
dc.date.available2018-05-22T14:58:45Z
dc.date.issued2018-05-10
dc.date.submitted2018-05-18
dc.identifier.citationNew insights into leishmaniasis in the immunosuppressed. 2018, 12 (5):e0006375 PLoS Negl Trop Disen
dc.identifier.issn1935-2735
dc.identifier.pmid29746470
dc.identifier.doi10.1371/journal.pntd.0006375
dc.identifier.urihttp://hdl.handle.net/10144/619163
dc.description.abstractImmunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas.
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsArchived with thanks to PLoS Neglected Tropical Diseasesen
dc.titleNew insights into leishmaniasis in the immunosuppresseden
dc.identifier.journalPLoS Neglected Tropical Diseasesen
refterms.dateFOA2019-03-04T14:00:25Z
html.description.abstractImmunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas.


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