• Login
    View Item 
    •   Home
    • 4 Research Resources
    • MSF Research Protocols
    • View Item
    •   Home
    • 4 Research Resources
    • MSF Research Protocols
    • View Item
    Jan 23, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    SURVEY OF PLASMODIUM FALCIPARUM SULFADOXINE/PYRIMETHAMINE (SP) RESISTANCE MARKERS IN MSF PROJECTS IN NORTH AND SOUTH KIVU, DR CONGO Short Title: SP Resistance Molecular Marker Prevalence Survey DRC

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    SP_protocol_MSF_ERB_changes_ac ...
    Size:
    759.6Kb
    Format:
    Microsoft Word 2007
    Description:
    Research Protocol
    DownloadPDF Variant
    Authors
    de Wit, Marit
    Rao, Bhargavi
    Lassovski, Maryvonne
    Ouabo, Adelaide
    Badjo, Colette
    Bousema, Teun
    Roper, Cally
    Okell, Lucy
    Piriou, Erwan
    Cibinda
    Affiliation
    MSF-OCA
    Issue Date
    2018-07
    
    Metadata
    Show full item record
    Abstract
    Primary Objective: To measure the prevalence of molecular markers of SP resistant malaria in North and South Kivu, DRC. Sulfadoxine/pyrimethamine (SP) forms the backbone of most malaria chemoprevention programmes in high endemicity settings, including intermittent preventative therapy in pregnancy and infants (IPTp and IPTi respectively) as well as seasonal malaria chemoprevention (SMC). P. falciparum parasite resistance to SP threatens recent triumphs preventing malaria infection in the most vulnerable risk groups. WHO guidance is that chemoprevention using SP may not be implemented when prevalence of the dhps K540E gene denoting SP resistance are greater than 50%. Simple, robust polymerase chain reaction (PCR) - based methods for molecular surveillance of resistance to SP have the potential to indicate whether SP-based chemoprevention programmes would be effective in areas where surveillance was conducted, but also to identify early stages of emerging resistance in order to advocate for alternative chemoprevention strategies.A minimum of 750 samples will be collected per province. Three sites per province will provide 250 samples assuming an estimated prevalence of 50% prevalence of dhps K540E gene with 95% confidence and 5% precision. This is also sufficient for robust estimation of the prevalence of dhps 581, an alternative critical marker. This sample size is calculated to estimate regional prevalence, i.e. for both South Kivu and North Kivu, and hence this study requires samples from multiple MSF sites (including from different MSF Operating Centre missions) e.g. Baraka, Kimbi and Lulingu amongst others in South Kivu and Mweso, Rutsuru and Walikale in North Kivu with a minimum total of 750 per province. If estimating specific prevalence in only one limited site, a large sample size would be required.
    URI
    http://hdl.handle.net/10144/619222
    Type
    Other
    Language
    en
    Description
    Research Protocol
    Collections
    MSF Research Protocols

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.