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    Jan 17, 2021
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    A randomized trial of AmBisome monotherapy and combination of AmBisome and miltefosine for the treatment of VL in HIV positive patients in Ethiopia followed by secondary VL prophylactic treatment with pentamidine

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    1a_-_DNDi_Protocol_HIV_VL_FINA ...
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    Authors
    Hailu, Asrat
    Diro, Ermias
    Kolja, Stille
    Ritmeijer, Koert
    Yifru, Sisay
    Griensven, Johan van
    Zijstra, Ed
    Dorlo, Thomas
    Strub-Wougaft, Nathalie
    Bardonneau, Clelia
    Ellis, Sally
    Alexander, Neal
    Edwards, Tansy
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    Affiliation
    MSF-OCA
    Issue Date
    2018-07
    
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    Abstract
    General Objectives The overall objective of this trial is to identify a safe and effective treatment for VL in HIV coinfected patients. Primary Objective: To evaluate at day 29 assessment the efficacy of a combination regimen of AmBisome® + miltefosine and AmBisome® monotherapy in Ethiopian co-infected HIV + VL patients. Secondary Objectives: 1. To evaluate relapse-free survival at day 390 (after initial cure at day 29 or cure at day 58 after extended treatment). 2. To assess safety of the regimens. Other objectives: 1.To evaluate of viral load and CD4 count in all patients 2. To evaluate the pharmacokinetics of ARV, Ambisome and miltefosine and immune function markers in a subset of patients
    URI
    http://hdl.handle.net/10144/619245
    Type
    Other
    Language
    en
    Description
    Research Protocol
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    MSF Research Protocols

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