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    Jan 16, 2021
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    Reactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study

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    Cooper et al - 2018 - Reactive ...
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    Authors
    Cooper, BS
    White, LJ
    Siddiqui, R
    Issue Date
    2018-09-25
    Submitted date
    2018-10-04
    
    Metadata
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    Journal
    PLoS Neglected Tropical Diseases
    Abstract
    Hepatitis E Virus (HEV) is the leading cause of acute viral hepatitis globally. Symptomatic infection is associated with case fatality rates of ~20% in pregnant women and it is estimated to account for ~10,000 annual pregnancy-related deaths in southern Asia alone. Recently, large and well-documented outbreaks with high mortality have occurred in displaced population camps in Sudan, Uganda and South Sudan. However, the epidemiology of HEV is poorly defined, and the value of different immunisation strategies in outbreak settings uncertain. We aimed to estimate the critical epidemiological parameters for HEV and to evaluate the potential impact of both reactive vaccination (initiated in response to an epidemic) and pre-emptive vaccination.
    Publisher
    Public Library of Science
    URI
    http://hdl.handle.net/10144/619278
    DOI
    10.1371/journal.pntd.0006807
    PubMed ID
    30252843
    Language
    en
    ISSN
    1935-2735
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pntd.0006807
    Scopus Count
    Collections
    Vaccination

    entitlement

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