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dc.contributor.authorWhitfield, KC
dc.contributor.authorBourassa, MW
dc.contributor.authorAdamolekun, B
dc.contributor.authorBergeron, G
dc.contributor.authorBettendorff, L
dc.contributor.authorBrown, KH
dc.contributor.authorCox, L
dc.contributor.authorFattal-Valevski, A
dc.contributor.authorFischer, PR
dc.contributor.authorFrank, EL
dc.contributor.authorHiffler, L
dc.contributor.authorHlaing, LM
dc.contributor.authorJefferds, ME
dc.contributor.authorKapner, H
dc.contributor.authorKounnavong, S
dc.contributor.authorMousavi, MPS
dc.contributor.authorRoth, DE
dc.contributor.authorTsaloglou, MN
dc.contributor.authorWieringa, F
dc.contributor.authorCombs, GF
dc.date.accessioned2018-10-16T17:02:01Z
dc.date.available2018-10-16T17:02:01Z
dc.date.issued2018-08-27
dc.date.submitted2018-09-20
dc.identifier.citationThiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. 2018 Ann. N. Y. Acad. Sci.en
dc.identifier.issn1749-6632
dc.identifier.pmid30151974
dc.identifier.doi10.1111/nyas.13919
dc.identifier.urihttp://hdl.handle.net/10144/619293
dc.description.abstractThiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.
dc.language.isoenen
dc.publisherWileyen
dc.rightsArchived with thanks to Annals of the New York Academy of Sciencesen
dc.titleThiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programsen
dc.identifier.journalAnnals of the New York Academy of Sciencesen
refterms.dateFOA2019-03-04T14:11:30Z
html.description.abstractThiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.


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