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    Jan 16, 2021
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    Prevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda

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    Migisha et al - 2018 - Prevalence ...
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    Authors
    Migisha, R
    Dan N
    Boum, Y
    Page, AL
    Zúñiga-Ripa, A
    Conde-Álvarez, R
    Bagenda, F
    Bonnet, M
    Issue Date
    2018-10-18
    Submitted date
    2018-11-01
    
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    Journal
    Scientific Reports
    Abstract
    Human brucellosis, a chronic disease contracted through contact with animals and consuption of unpasteurized dairy products is underreported in limited-resource countries. This cross-sectional study aimed to determine the prevalence and risk factors of brucellosis among febrile patients attending a community hospital in South western Uganda. A questionnaire that captured socio-demographic, occupational and clinical data was administered. Blood samples were tested for Brucella antibodies using Rose Bengal Plate Test (RBPT) and blood culture with standard aerobic BACTEC bottle was done. Of 235 patients enrolled, prevalence of brucellosis (RBPT or culture confirmed) was 14.9% (95% CI 10.6-20.1) with a culture confrmation in 4.3% of the participants. The factors independently associated with brucellosis were consumption of raw milk (aOR 406.15, 95% CI 47.67-3461.69); history of brucellosis in the family (aOR 9.19, 95% CI 1.98-42.54); and selling hides and skins (aOR 162.56, 95% CI 2.86-9256.31). Hepatomegaly (p < 0.001), splenomegaly (p = 0.018) and low body mass index (p = 0.032) were more common in patients with brucellosis compared to others. Our findings reveal a high prevalence of brucellosis among febrile patients and highlight a need for implementing appropiate tests, public awareness activities and vaccination of animals to control and eliminate the disease.
    Publisher
    Nature Research
    URI
    http://hdl.handle.net/10144/619298
    DOI
    10.1038/s41598-018-33915-9
    PubMed ID
    30337685
    Language
    en
    ISSN
    2045-2322
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-018-33915-9
    Scopus Count
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