High treatment success rate for multidrug-resistant and extensively drug-resistant tuberculosis using a bedaquiline-containing treatment regimen
Authors
Ndjeka, NSchnippel, K
Master, I
Meintjes, G
Maartens, G
Romero, R
Padanilam, X
Enwerem, M
Chotoo, S
Singh, N
Hughes, J
Variava, E
Ferreira, H
Te Riele, J
Ismail, N
Mohr, E
Bantubani, N
Conradie, F
Issue Date
2018-10-25Submitted date
2018-11-05
Metadata
Show full item recordJournal
The European Respiratory JournalAbstract
Background: South African patients with rifampicin-resistant tuberculosis and resistance to fluoroquinolones and/or injectables (pre/XDR-TB) were granted access to bedaquiline through a Clinical Access Programme with strict inclusion and exclusion criteria.Methods: Pre/XDR-TB and XDR-TB patients were treated with 24 weeks bedaquiline within an optimised, individualised background regimen that could include levofloxacin, linezolid and clofazimine as needed.Results: 200 patients were enrolled: 87 (43.9%) with XDR-TB, 99 (49.3%) were female, median age 34 years (IQR 27, 42). 134 (67.0%) were living with HIV; median CD4+ 281 (IQR 130; 467) and all on antiretroviral therapy.16/200 patients (8.0%) did not complete 6 months of bedaquiline of which 8 were lost to follow up, 6 died, 1 stopped for side effects and 1 patient was diagnosed with drug-sensitive TB.146/200 (73.0%) patients had favourable outcomes: 139/200 were cured (69.5%) and 7 completed treatment (3.5%). 25 died (12.5%), were lost from treatment (10.0%), 9 had treatment failure (4.5%).22 adverse events were attributed to bedaquiline: including QTcF >500 ms (n=5), QTcF increase >50 ms from baseline (n=11), paroxysmal atrial flutter (n=1).Conclusion: Bedaquiline added to an optimised background regimen was associated with a high rate of successful treatment outcomes for this MDR-TB and XDR-TB cohort.Publisher
European Respiratory SocietyPubMed ID
30361246Language
enDescription
We regret that this article is behind a paywall.ISSN
1399-3003ae974a485f413a2113503eed53cd6c53
10.1183/13993003.01528-2018